2型糖尿病是胰腺β细胞的糖原贮积病吗？
Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?
作者信息
Ashcroft Frances M, Rohm Maria, Clark Anne, Brereton Melissa F
机构信息
Department of Physiology, Anatomy, and Genetics and OXION, University of Oxford, Parks Road, Oxford OX1 3PT, UK.
Department of Physiology, Anatomy, and Genetics and OXION, University of Oxford, Parks Road, Oxford OX1 3PT, UK.
出版信息
Cell Metab. 2017 Jul 5;26(1):17-23. doi: 10.1016/j.cmet.2017.05.014.
Abstract
Elevated plasma glucose leads to pancreatic β cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting β cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in β cells in normoglycemia and in diabetes.
摘要
血糖升高会导致2型糖尿病患者的胰腺β细胞功能障碍和死亡。由于代谢受损导致的糖原积累，通过促进β细胞功能障碍的生化途径失调，促成了这种“糖毒性”。在此，我们回顾了有关糖原在正常血糖和糖尿病状态下β细胞中作用的新数据，并重新审视了已发表的研究结果。
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