哇塞！哺乳动物中意想不到的蛋白质甘露糖基化途径。
Whoa man! Unexpected protein -mannosylation pathways in mammals.
作者信息
Sheikh M Osman, Wells Lance
机构信息
From the Complex Carbohydrate Research Center and.
From the Complex Carbohydrate Research Center and
出版信息
J Biol Chem. 2017 Jul 7;292(27):11599-11600. doi: 10.1074/jbc.H117.794487.
Abstract
The recent expansion of well-characterized -mannosylated mammalian proteins beyond the archetypical example of α-dystroglycan has inspired new interest in the possibility of additional functional roles of this modification. In an effort to explore those roles, a new study now serendipitously uncovers the existence of an alternative pathway to the well-described POMT (protein -mannosyltransferase) family of -mannosyltransferases.
摘要
除了典型的α-肌营养不良蛋白外，最近已明确特征的O-甘露糖基化哺乳动物蛋白的扩展激发了人们对这种修饰可能具有的其他功能作用的新兴趣。为了探索这些作用，一项新研究意外地发现了一条不同于已充分描述的O-甘露糖基转移酶POMT（蛋白O-甘露糖基转移酶）家族的替代途径的存在。
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