Vaccine. 2017 Oct 13;35(43):5751-5752. doi: 10.1016/j.vaccine.2017.06.087. Epub 2017 Jul 6.
This article presents the World Health Organization's (WHO) recommendations on the use of fractional doses of yellow fever vaccines excerpted from the "Yellow fever vaccine: WHO position on the use of fractional doses - June 2017, Addendum to Vaccines and vaccination against yellow fever WHO: Position Paper - June 2013″, published in the Weekly Epidemiological Record [1,2]. This addendum to the 2013 position paper pertains specifically to use of fractional dose YF (fYF) vaccination (fractional dose yellow fever vaccination refers to administration of a reduced volume of vaccine dose, which has been reconstituted as usual per manufacturer recommendations) in the context of YF vaccine supply shortages beyond the capacity of the global stockpile. The current WHO position on the use of yellow fever (YF) vaccine is set out in the 2013 WHO position paper on vaccines and vaccination against YF and those recommendations are unchanged. Footnotes to this paper provide a number of core references including references to grading tables that assess the quality of the scientific evidence, and to the evidence-to-recommendation table. In accordance with its mandate to provide guidance to Member States on health policy matters, WHO issues a series of regularly updated position papers on vaccines and combinations of vaccines against diseases that have an international public health impact. These papers are concerned primarily with the use of vaccines in large-scale immunization programmes; they summarize essential background information on diseases and vaccines, and conclude with WHO's current position on the use of vaccines in the global context. Recommendations on the use of Yellow Fever vaccines were discussed by SAGE in October 2016; evidence presented at these meetings can be accessed at: www.who.int/immunization/sage/meetings/2016/October/presentations_background_docs/en/.
本文介绍了世界卫生组织（WHO）关于使用黄热病疫苗分剂量的建议，内容摘自《黄热病疫苗：WHO关于使用分剂量的立场——2017年6月，<疫苗与黄热病疫苗接种：WHO立场文件——2013年6月>增编》，发表于《疫情周报》[1,2]。2013年立场文件的这份增编专门涉及在全球储备能力之外黄热病疫苗供应短缺的情况下使用黄热病疫苗分剂量接种（分剂量黄热病疫苗接种是指接种按制造商常规建议复溶后体积减少的疫苗剂量）。WHO目前关于使用黄热病（YF）疫苗的立场载于2013年WHO关于黄热病疫苗接种的立场文件，这些建议未变。本文脚注提供了一些核心参考文献，包括评估科学证据质量的分级表参考文献以及证据与建议表参考文献。根据其向会员国提供卫生政策事项指导的任务，WHO发布了一系列定期更新的关于对具有国际公共卫生影响的疾病使用疫苗及疫苗组合的立场文件。这些文件主要涉及疫苗在大规模免疫规划中的使用；它们总结了关于疾病和疫苗的基本背景信息，并以WHO目前在全球范围内使用疫苗的立场作为结论。免疫战略咨询专家组（SAGE）于2016年10月讨论了关于使用黄热病疫苗的建议；这些会议上展示的证据可在以下网址查阅：www.who.int/immunization/sage/meetings/2016/October/presentations_background_docs/en/ 。
