Rodriguez-Sanchez M N, Arilla E
Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Madrid, Spain.
Biosci Rep. 1989 Apr;9(2):199-206. doi: 10.1007/BF01115996.
Hypoglycemia was induced by administration of insulin (40 I.U./kg) to 24 h fasted rats. Somatostatin-like immunoreactivity (SLI) and 125I-Tyr11-somatostatin binding were measured in the striatum and hypothalamus at the onset of hypoglycemic coma (5-10 min). No significant changes in SLI concentration were detected in either site although the total number of specific somatostatin receptors in the striatum membranes, but not in the hypothalamus, decreased in insulin-injected rats when compared with the control group.
通过给禁食24小时的大鼠注射胰岛素（40国际单位/千克）诱导低血糖。在低血糖昏迷开始时（5 - 10分钟），测量纹状体和下丘脑的生长抑素样免疫反应性（SLI）以及125I - Tyr11 - 生长抑素结合情况。尽管与对照组相比，注射胰岛素的大鼠纹状体膜中特异性生长抑素受体的总数减少，但下丘脑未出现这种情况，不过在这两个部位均未检测到SLI浓度的显著变化。
