Li Sisi, Lu Zhifang, Yao Mengwei, Ning Sisi, Wu Yuan, Zhou Xunzhao, Zhong Changtao, Yan Kui, Xie Ying, Wei Zhengbo
Department of Head and Neck Tumor Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
Graduate School of Guangxi Medical University, Nanning, China.
Dis Markers. 2017;2017:6309754. doi: 10.1155/2017/6309754. Epub 2017 Jun 14.
The aim of this study was to explore potential relationships of four single-nucleotide polymorphisms (SNPs) in the gene encoding dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) with risk of nasopharyngeal carcinoma (NPC). The DC-SIGN SNPs rs7252229, rs4804803, rs2287886, and rs735240 were genotyped in 477 unrelated NPC patients and 561 cancer-free controls. At rs7252229, risk of NPC was significantly lower in individuals with GC (odds ratio [OR] 0.076, 95% confidence interval [CI] 0.008-0.690), GG (OR 0.056, 95%CI 0.006-0.487), or GC + GG (OR 0.059, 95%CI 0.007-0.515) than in individuals with the CC genotype, after adjusting for age, gender, smoking history, and EBV-VCA-IgA status. At rs4804803, risk of NPC was significantly higher in individuals with the genotype GG than in those with the genotype AA (adjusted OR 9.038, 95%CI 1.708-47.822). At rs735240, risk of NPC did not change significantly with genotypes AG, GG, or AG + GG after adjusting for age, gender, and smoking history. However, when data were also adjusted for EBV-VCA-IgA status, three genotypes emerged as associated with significantly higher risk of NPC than the AA genotype: AG (OR 2.976, 95%CI 1.123-7.888), GG (OR 3.314, 95%CI 1.274-8.622), or GG + AG (OR 3.191, 95%CI 1.237-8.230). Our results suggest that DC-SIGN SNPs rs7252229, rs4804803, and rs735240 may influence NPC risk in the Chinese population. The mechanisms mediating this risk require a further study.
本研究旨在探讨树突状细胞特异性细胞间黏附分子3结合非整合素（DC-SIGN）编码基因中的四个单核苷酸多态性（SNP）与鼻咽癌（NPC）风险之间的潜在关系。对477名无亲缘关系的NPC患者和561名无癌对照者进行了DC-SIGN SNPs rs7252229、rs4804803、rs2287886和rs735240的基因分型。在rs7252229位点，在调整年龄、性别、吸烟史和EBV-VCA-IgA状态后，GC（比值比[OR]0.076，95%置信区间[CI]0.008 - 0.690）、GG（OR 0.056，95%CI 0.006 - 0.487）或GC + GG（OR 0.059，95%CI 0.007 - 0.515）基因型个体患NPC的风险显著低于CC基因型个体。在rs4804803位点，GG基因型个体患NPC的风险显著高于AA基因型个体（调整后OR 9.038，95%CI 1.708 - 47.822）。在rs735240位点，在调整年龄、性别和吸烟史后，AG、GG或AG + GG基因型个体患NPC的风险无显著变化。然而，当数据也根据EBV-VCA-IgA状态进行调整时，出现三种基因型与患NPC的风险显著高于AA基因型相关：AG（OR 2.976，95%CI 1.123 - 7.888）、GG（OR 3.314，95%CI 1.274 - 8.622）或GG + AG（OR 3.191，95%CI 1.237 - 8.230）。我们的结果表明，DC-SIGN SNPs rs7252229、rs4804803和rs735240可能影响中国人群患NPC的风险。介导这种风险的机制需要进一步研究。
