Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands.
Autoimmun Rev. 2017 Sep;16(9):951-962. doi: 10.1016/j.autrev.2017.07.008. Epub 2017 Jul 8.
The endothelium is crucially important for the delivery of oxygen and nutrients throughout the body under homeostatic conditions. However, it also contributes to pathology, including the initiation and perpetuation of inflammation. Understanding the function of endothelial cells (ECs) in inflammatory diseases and molecular mechanisms involved may lead to novel approaches to dampen inflammation and restore homeostasis. In this article, we discuss the various functions of ECs in inflammation with a focus on pathological angiogenesis, attraction of immune cells, antigen presentation, immunoregulatory properties and endothelial-to-mesenchymal transition (EndMT). We also review the current literature on approaches to target these processes in ECs to modulate immune responses and advance anti-inflammatory therapies.
内皮细胞在维持体内稳态时对于氧气和营养物质的输送至关重要。然而，它也会导致病理学的发生，包括炎症的启动和持续。了解内皮细胞在炎症性疾病中的功能和涉及的分子机制可能会为抑制炎症和恢复内稳态提供新的方法。在本文中，我们讨论了内皮细胞在炎症中的各种功能，重点是病理性血管生成、免疫细胞的趋化、抗原呈递、免疫调节特性和内皮细胞向间充质转化（EndMT）。我们还回顾了目前针对这些内皮细胞过程的靶向方法的文献，以调节免疫反应并推进抗炎治疗。
