State Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, DongdanSantiao 5# Dongcheng District, Beijing, 100730, China.
School of Life Sciences, Tsinghua University, Haidian District, Beijing, 00084, China.
Neurochem Res. 2017 Nov;42(11):3140-3148. doi: 10.1007/s11064-017-2351-4. Epub 2017 Jul 11.
Lipid bodies (LBs) have long been considered to be organelles merely for the storage of neutral lipids. However, recent studies have shown the significance of LBs in signal transduction, especially in glial cells, including microglia. Microglial cells are the resident mononuclear phagocytes in the central nervous system and have a close relationship with the aging process and neurodegenerative diseases. Evidence suggests that LBs accumulate and are remodeled during the aging process and the development of neuroinflammatory conditions. However, the mechanisms underlying the formation of LBs under these conditions and the mechanism by which LB remodeling influences the progression of neurodegeneration remain to be clarified. In this review, we have summarized the findings from recent studies with the aim of further elucidating these issues.
脂滴（Lipid bodies，LBs）长期以来一直被认为仅仅是用于储存中性脂质的细胞器。然而，最近的研究表明，LBs 在信号转导中具有重要意义，尤其是在神经胶质细胞中，包括小胶质细胞。小胶质细胞是中枢神经系统中常驻的单核吞噬细胞，与衰老过程和神经退行性疾病密切相关。有证据表明，在衰老过程中和神经炎症条件下，LBs 会积累并进行重塑。然而，在这些条件下 LB 形成的机制以及 LB 重塑影响神经退行性病变进展的机制仍有待阐明。在这篇综述中，我们总结了最近的研究结果，旨在进一步阐明这些问题。
