食用阿甘油对膝关节骨关节炎症状的有效性：一项随机对照临床试验。

Effectiveness of Argan Oil Consumption on Knee Osteoarthritis Symptoms: A Randomized Controlled Clinical Trial.

作者信息

Essouiri Jamila, Harzy Taoufik, Benaicha Nadia, Errasfa Mourad, Abourazzak Fatima Ezzahra

机构信息

Department of Rheumatology, University Hospital Hassan II, University of Sidi Mohamed Ben Abdellah, Fez. Morocco.

Department of Epidemiology, Faculty of Medicine and Pharmacy, University of Sidi Mohamed Ben Abdellah, Fez. Morocco.

出版信息

Curr Rheumatol Rev. 2017;13(3):231-235. doi: 10.2174/1573397113666170710123031.

DOI:10.2174/1573397113666170710123031

PMID:28699499

Abstract

BACKGROUND

Knee osteoarthritis (KOA) is a common chronic degenerative disorder. It causes joint pain, walking difficulties and a decline in general physical function. Many pain drugs and treatment modalities can be prescribed for KOA. Among traditional medicines in Morocco, Argan oil has been used in the treatment of knee osteoarthritis to reduce pain and improve physical activity, though there have been no medical-based evidence for such treatment. Argan oil is known to have anti-oxidant and lipid modulatory properties due to its content of many substances, such as tocopherols, phytosterols, saturated and unsaturated fatty acids.

OBJECTIVES

This study was undertaken in order to investigate the effect of daily consumption of culinary argan oil on KOA symptoms.

PATIENTS AND METHODS

We conducted a randomized controlled clinical trial on patients with KOA according to the American College of Rheumatology (ACR) criteria. Patients were divided into 2 groups: argan oil group who received argan oil to be consumed every morning (30 ml per day) for 8 weeks and control group with no treatment. Clinical assessment before and after 8 weeks study was performed by several tests such as the Visual Analogue Scale (VAS) for pain, walking perimeter, the Western Ontario and McMaster Universities osteoarthritis index (WOMAC), and the Lequesne index.

RESULTS

The study included 100 patients. 51 patients were randomly assigned to argan oilgroup while 49 patients were randomly assigned to control group with no treatment. Mean age of our patients was 58.24 ± 7.2 years, with a majority of women (93%). Following 8 weeks of argan oil consumption, argan oil group had a very significant decrease of VAS for pain (p< 0.0001), with a significant decrease in WOMAC pain index (p < 0.0001), and improvement of WOMAC function index (p < 0.0001). Lequesne index (p < 0.0001) as well as walking distance (p =0,002) significantly improved. When data of argan oil group were compared to those of control group, we found statistically significant differences in all the above measured parameters: VAS of pain (P=0,02), WOMAC pain (p<0,0001), WOMAC function (p<0,0001), walking distance (p=0,001) and lequesne index (p<0,0001).

CONCLUSION

Patient's consumption of argan oil seems to be safe and efficacious in improving clinical symptoms of KOA.

摘要

背景

膝关节骨关节炎（KOA）是一种常见的慢性退行性疾病。它会导致关节疼痛、行走困难以及整体身体功能下降。治疗KOA可以开具多种止痛药物和治疗方式。在摩洛哥的传统药物中，阿甘油已被用于治疗膝关节骨关节炎以减轻疼痛和改善身体活动能力，尽管尚无基于医学的此类治疗证据。由于阿甘油含有多种物质，如生育酚、植物甾醇、饱和脂肪酸和不饱和脂肪酸，已知其具有抗氧化和脂质调节特性。

目的

本研究旨在调查每日食用烹饪用阿甘油对KOA症状的影响。

患者与方法

我们根据美国风湿病学会（ACR）标准对KOA患者进行了一项随机对照临床试验。患者分为两组：阿甘油组，每天早上服用阿甘油（每天30毫升），持续8周；对照组不进行治疗。在8周研究前后，通过多种测试进行临床评估，如疼痛视觉模拟量表（VAS）、行走周长、西安大略和麦克马斯特大学骨关节炎指数（WOMAC）以及勒凯斯内指数。

结果

该研究纳入了100名患者。51名患者被随机分配到阿甘油组，49名患者被随机分配到不进行治疗的对照组。我们患者的平均年龄为58.24±7.2岁，大多数为女性（93%）。食用阿甘油8周后，阿甘油组的疼痛VAS显著降低（p<0.0001），WOMAC疼痛指数显著降低（p<0.0001），WOMAC功能指数有所改善（p<图0.0001）。勒凯斯内指数（p<0.0001）以及行走距离（p =0.002）也显著改善。当将阿甘油组的数据与对照组的数据进行比较时，我们发现在上述所有测量参数上均存在统计学显著差异：疼痛VAS（P=0.02）、WOMAC疼痛（p<0.0001）、WOMAC功能（p<0.0001）、行走距离（p=0.001）和勒凯斯内指数（p<0.0001）。