Department of Vascular Surgery/Medical School Twente, Medisch Spectrum Twente, Enschede, Netherlands.
Curr Med Chem. 2018;25(41):5772-5781. doi: 10.2174/0929867324666170710120556.
A major global health issue is the existence of chronic wounds. Appropriate diagnosis and treatment is essential to promote wound healing and prevent further complications. Traditional methods for treatment and diagnosis of chronic wounds have shown to be of limited effectiveness. Therefore, there is a need for the development of diagnostic and therapeutic innovations in chronic wound care.
This mini-review aims to provide insight in the current knowledge of the wound healing process and the deficiencies encountered in chronic wounds, which provides a basis for the development of innovations in chronic wound care. Furthermore, promising diagnostic and therapeutic innovations will be highlighted.
Literature was searched for recent articles (=<10 years) describing the current knowledge about the wound healing process and chronic wounds. The most promising diagnostic and therapeutic innovations were gathered from articles published in the past 5 years.
RESULTS/CONCLUSION: Wound healing is a well-organized process consisting of four phases: coagulation, inflammation, proliferation and wound remodelling. Chronic wounds often stagnate in the inflammatory phase and/or experience an impaired proliferative phase. This mini-review has demonstrated that increased knowledge about the processes involved in wound healing has paved the way for the development of new diagnostic tools and treatments for chronic wounds. Increased knowledge about bacterial invasion and infection in has encouraged researchers to develop diagnostic tools to help clinicians detect these phenomena appropriately and in time. Other researchers have shown that they are able to design/extract biochemical compounds that intervene in the disrupted healing processes in chronic wounds.
慢性伤口是全球主要的健康问题之一。为促进伤口愈合并预防进一步的并发症，对其进行恰当的诊断和治疗至关重要。传统的慢性伤口治疗和诊断方法效果有限。因此，需要开发慢性伤口护理的诊断和治疗创新。
本迷你综述旨在深入了解伤口愈合过程的现有知识以及慢性伤口中存在的缺陷，为慢性伤口护理的创新发展提供基础。此外，还将重点介绍有前途的诊断和治疗创新。
检索了近 10 年内描述伤口愈合过程和慢性伤口的最新文献。从过去 5 年内发表的文章中收集了最有前途的诊断和治疗创新。
结果/结论：伤口愈合是一个组织良好的过程，由四个阶段组成：凝血、炎症、增殖和伤口重塑。慢性伤口常停滞在炎症阶段和/或经历受损的增殖阶段。本综述表明，对伤口愈合过程的深入了解为慢性伤口的新诊断工具和治疗方法的开发铺平了道路。对细菌入侵和感染的认识增加，促使研究人员开发诊断工具，以帮助临床医生及时、恰当地发现这些现象。其他研究人员已经表明，他们能够设计/提取干预慢性伤口中受损愈合过程的生化化合物。
