Shao Haibo, Ma Tengchuang, Hong Duo, Xu Wenhuan, Li Shuai, Arellano Ronald S, Xu Ke
Department of Interventional Radiology, The First Hospital of China Medical University, Shenyang, 110001, China.
Division of Interventional Radiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, United States.
Curr Drug Metab. 2018;19(2):94-99. doi: 10.2174/1389200218666170710185906.
Nano-oncology and interventional oncology are both rapidly emerging fields in cancer therapies. Synergistic combination of the both fields offers drastic improvements in performance and efficacy of cancer killing agents.
This review is to overview the studies focusing on these two crossing fields and to give an overlook of their future development. Interventional techniques such as selective arterial catheterization, irreversible electroporation (IRE) and radiofrequency ablation (RFA) dramatically enhanced cancer targetability and anticancer efficacy of nanoparticles (NPs). Furthermore, synergistic effects were observed when using different interventional techniques together on NPs directed cancer treatments. On the other hand, NPs improved thermal ablation as well by fundamentally improving heating efficiency, facilitating heat triggered local drug delivery, and increasing cancer control in marginal peri-ablated zones and distant regions.
Crossing applications of the both techniques such as percutaneous delivery of near infrared (NIR) into deep tumors by needle insertion and conformal thermal ablation are highly anticipated.
纳米肿瘤学和介入肿瘤学都是癌症治疗中迅速兴起的领域。这两个领域的协同结合可显著提高癌症杀伤剂的性能和疗效。
本综述旨在概述聚焦于这两个交叉领域的研究，并展望其未来发展。诸如选择性动脉插管、不可逆电穿孔（IRE）和射频消融（RFA）等介入技术显著增强了纳米颗粒（NPs）的癌症靶向性和抗癌疗效。此外，在针对纳米颗粒的癌症治疗中联合使用不同介入技术时可观察到协同效应。另一方面，纳米颗粒也通过从根本上提高加热效率、促进热触发的局部药物递送以及增强边缘消融周边区域和远处区域的癌症控制，改善了热消融效果。
人们高度期待这两种技术的交叉应用，例如通过针插入将近红外（NIR）经皮递送至深部肿瘤以及适形热消融。
