Department of Prosthodontics/Dental Materials Science, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Periodontics, 618th Dental Company, Camp Humphreys, Pyeongtaek, Korea.
J Clin Periodontol. 2017 Sep;44(9):941-949. doi: 10.1111/jcpe.12776. Epub 2017 Aug 23.
The objective of this study was to evaluate whether surface chemistry-controlled TiO nanotube structures may serve as a local drug delivery system for zoledronic acid improving implant-bone support.
Twenty-four screw-shaped Ti implants with surface chemistry-controlled TiO nanotube structures were prepared and divided into a zoledronic acid-formatted test and a native control group. The implants were inserted into contra-lateral femoral condyles in 12 New Zealand White rabbits. Bone support was evaluated using resonance frequency analysis (RFA) and removal torque (RTQ), as well as histometric analysis following a 3-weeks healing interval.
Zoledronic acid-formatted TiO nanotube test implants showed significantly improved implant stability and osseointegration measured using RFA and RTQ compared with control (p < 0.05), and showed significantly enhanced new bone formation within the root of the threads compared with control (p < 0.05).
TiO nanotube implants may prove to be a significant delivery system for drugs or biologic agents aimed at supporting local bone formation. Additional study of candidate drugs/agents, optimized dosage and release kinetics is needed prior to evaluation in clinical settings.
本研究旨在评估表面化学控制的 TiO 纳米管结构是否可作为一种局部药物输送系统，以提高唑来膦酸改善种植体-骨支持。
制备了 24 个具有表面化学控制的 TiO 纳米管结构的螺旋状 Ti 植入物，并分为唑来膦酸格式化测试组和天然对照组。将植入物插入 12 只新西兰白兔的对侧股骨髁。使用共振频率分析（RFA）和去除扭矩（RTQ）以及 3 周愈合间隔后的组织学分析来评估骨支持。
与对照组相比，唑来膦酸格式化 TiO 纳米管测试植入物的 RFA 和 RTQ 测量显示出明显改善的植入物稳定性和骨整合（p < 0.05），并且在螺纹根部显示出明显增强的新骨形成（p < 0.05）。
TiO 纳米管植入物可能被证明是一种用于支持局部骨形成的药物或生物制剂的重要输送系统。在临床评估之前，需要对候选药物/制剂、优化剂量和释放动力学进行进一步研究。
