Chemical Research and Development, Pfizer, Inc. , Eastern Point Road, Groton, Connecticut 06340, United States.
Org Lett. 2017 Jul 21;19(14):3755-3758. doi: 10.1021/acs.orglett.7b01598. Epub 2017 Jul 13.
A constant-current electrochemical method for reducing catalytic nickel complexes in sp-sp cross-electrophile coupling reactions has been developed. The electrochemical reduction provides reliable nickel catalyst activation and turnover and offers a tunable parameter for reaction optimization, in contrast to more standard activated metal powder reductants. The electrochemical reactions give yields (i.e., 51-86%) and selectivities as high or superior to those using metal powder reductants and provide access to a wider substrate scope.
已开发出一种用于 sp-sp 交叉亲电偶联反应中还原催化性镍络合物的恒流电化学方法。与更标准的活化金属粉末还原剂相比，电化学还原提供了可靠的镍催化剂活化和转化，并为反应优化提供了可调参数。电化学反应的产率（即 51-86%）和选择性与使用金属粉末还原剂相当或更高，并提供了更广泛的底物范围。
