佩托悖论：进化是如何解决癌症预防问题的？
Peto's Paradox: how has evolution solved the problem of cancer prevention?
机构信息
Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, 727 E. Tyler St., Tempe, AZ, 85287-5001, USA.
出版信息
BMC Biol. 2017 Jul 13;15(1):60. doi: 10.1186/s12915-017-0401-7.
The risk of developing cancer should theoretically increase with both the number of cells and the lifespan of an organism. However, gigantic animals do not get more cancer than humans, suggesting that super-human cancer suppression has evolved numerous times across the tree of life. This is the essence and promise of Peto's Paradox. We discuss what is known about Peto's Paradox and provide hints of what is yet to be discovered.
从理论上讲，细胞数量和生物体寿命的增加都会增加患癌症的风险。然而，巨大的动物并不会比人类更容易患上癌症，这表明超级人类的癌症抑制已经在生命之树上多次进化。这就是 Peto 悖论的本质和承诺。我们将讨论已知的 Peto 悖论，并提供尚未发现的内容的提示。
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