Kashyap Dharambir, Tuli Hardeep Singh, Sharma Anil K
Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab 160012, India.
Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India.
Life Sci. 2016 Feb 1;146:201-13. doi: 10.1016/j.lfs.2016.01.017. Epub 2016 Jan 14.
Plants are known to produce a variety of bioactive metabolites which are being used to cure various life threatening and chronic diseases. The molecular mechanism of action of such bioactive molecules, may open up new avenues for the scientific community to develop or improve novel therapeutic approaches to tackle dreadful diseases such as cancer and cardiovascular and neurodegenerative disorders. Ursolic acid (UA) is one among the categories of such plant-based therapeutic metabolites having multiple intracellular and extracellular targets that play role in apoptosis, metastasis, angiogenesis and inflammatory processes. Moreover, the synthetic derivatives of UA have also been seen to be involved in a range of pharmacological applications, which are associated with prevention of diseases. Evidences suggest that UA could be used as a potential candidate to develop a comprehensive competent strategy towards the treatment and prevention of health disorders. The review article herein describes the possible therapeutic effects of UA along with putative mechanism of action.
众所周知，植物会产生多种生物活性代谢产物，这些产物正被用于治疗各种危及生命的慢性疾病。此类生物活性分子的分子作用机制，可能为科学界开辟新途径，以开发或改进新型治疗方法，来应对诸如癌症、心血管疾病和神经退行性疾病等可怕疾病。熊果酸（UA）是此类基于植物的治疗性代谢产物之一，具有多个细胞内和细胞外靶点，在细胞凋亡、转移、血管生成和炎症过程中发挥作用。此外，UA的合成衍生物也被发现参与了一系列与疾病预防相关的药理应用。有证据表明，UA可作为一种潜在候选物，用于制定全面有效的治疗和预防健康疾病的策略。本文的综述文章描述了UA可能的治疗作用及其假定的作用机制。
