Peripheral and Alveolar Cell Transcriptional Programs Are Distinct in Acute Respiratory Distress Syndrome.
作者信息
Morrell Eric D, Radella Frank, Manicone Anne M, Mikacenic Carmen, Stapleton Renee D, Gharib Sina A, Wurfel Mark M
机构信息
1 Harborview Medical Center Seattle, Washington.
2 University of Washington Seattle, Washington and.
出版信息
Am J Respir Crit Care Med. 2018 Feb 15;197(4):528-532. doi: 10.1164/rccm.201703-0614LE.
Abstract
摘要
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本文引用的文献
1
Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.早期脓毒症诱发的急性呼吸窘迫综合征患者中性粒细胞相关基因表达增加。
Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1102-13. doi: 10.1152/ajplung.00380.2014. Epub 2015 Mar 20.
2
Inflammasome-regulated cytokines are critical mediators of acute lung injury.炎性体调节的细胞因子是急性肺损伤的关键介质。
Am J Respir Crit Care Med. 2012 Jun 1;185(11):1225-34. doi: 10.1164/rccm.201201-0003OC. Epub 2012 Mar 29.
3
A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury.一项关于ω-3 脂肪酸治疗急性肺损伤的 II 期随机安慰剂对照试验。
Crit Care Med. 2011 Jul;39(7):1655-62. doi: 10.1097/CCM.0b013e318218669d.
4
Discovery of the gene signature for acute lung injury in patients with sepsis.脓毒症患者急性肺损伤基因特征的发现。
Physiol Genomics. 2009 Apr 10;37(2):133-9. doi: 10.1152/physiolgenomics.90275.2008. Epub 2009 Jan 27.
5
lumi: a pipeline for processing Illumina microarray.Lumi：一个用于处理Illumina微阵列的流程。
Bioinformatics. 2008 Jul 1;24(13):1547-8. doi: 10.1093/bioinformatics/btn224. Epub 2008 May 8.
6
A genome-wide expression analysis in blood identifies pre-elafin as a biomarker in ARDS.一项血液中的全基因组表达分析将前弹性蛋白作为急性呼吸窘迫综合征的生物标志物。
Am J Respir Cell Mol Biol. 2008 Jun;38(6):724-32. doi: 10.1165/rcmb.2007-0354OC. Epub 2008 Jan 18.
7
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.基因集富集分析：一种基于知识的方法用于解读全基因组表达谱。
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. doi: 10.1073/pnas.0506580102. Epub 2005 Sep 30.
8
TM4: a free, open-source system for microarray data management and analysis.TM4：一个用于微阵列数据管理与分析的免费开源系统。
Biotechniques. 2003 Feb;34(2):374-8. doi: 10.2144/03342mt01.
9
Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome.急性呼吸窘迫综合征持续存在患者体内的炎性细胞因子
Am J Respir Crit Care Med. 1996 Sep;154(3 Pt 1):602-11. doi: 10.1164/ajrccm.154.3.8810593.
10
Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups.白细胞介素-8与高危患者群体中成人呼吸窘迫综合征的发生发展
Lancet. 1993 Mar 13;341(8846):643-7. doi: 10.1016/0140-6736(93)90416-e.
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