Department of Periodontology, A.B. Shetty Memorial Institute of Dental Sciences, NITTE University, Deralakatte, Mangalore, Karnataka, India.
Department of Cardiology, K.S. Hegde Medical Academy, NITTE University, Deralakatte, Mangalore, Karnataka, India.
J Periodontol. 2017 Dec;88(12):1234-1243. doi: 10.1902/jop.2017.160748. Epub 2017 Jul 14.
The inflammatory burden as a result of severe periodontal disease acts as an insult to the endothelium. This disruption in the function of the endothelium predisposes it toward formation of atherosclerotic plaque, which may be a subsequent risk for coronary artery disease. The aim of this study is to estimate and compare endothelial function via flow-mediated dilation (FMD) assessment in periodontal health and disease.
A total of 120 patients were selected and categorized equally into three groups: 1) healthy (control); 2) chronic periodontitis (CP); and 3) myocardial infarction (MI). Periodontal inflamed surface area (PISA) and FMD were assessed in all patients. Fasting blood samples were collected to estimate lipid profile. Analysis of variance was used for comparison of lipid profile, whereas Kruskal-Wallis test was used for comparison of FMD and PISA scores among the study groups with P <0.05.
Comparison of FMD levels among the three groups showed statistically significant difference, with P <0.001. The value was statistically significant when the healthy group was compared with the CP and MI groups but not when the CP group was compared with the MI group. Lipid profile levels were statistically significant on comparison between the healthy and CP groups and between the CP and MI groups.
Endothelial function was impaired in patients with CP compared with healthy patients, and the dysfunction observed was similar to that observed in the MI group based on FMD values.
严重牙周病导致的炎症负担会损害内皮细胞。内皮细胞功能的这种破坏使其更容易形成动脉粥样硬化斑块，这可能是冠心病的后续风险因素。本研究旨在通过血流介导的扩张（FMD）评估来评估和比较牙周健康和疾病患者的内皮功能。
共选择了 120 名患者，并将其平均分为三组：1）健康（对照组）；2）慢性牙周炎（CP）；和 3）心肌梗死（MI）。所有患者均评估牙周炎炎症表面面积（PISA）和 FMD。采集空腹血样以评估血脂谱。方差分析用于比较血脂谱，而 Kruskal-Wallis 检验用于比较研究组之间的 FMD 和 PISA 评分，P<0.05。
三组之间的 FMD 水平比较显示具有统计学差异，P<0.001。当将健康组与 CP 和 MI 组进行比较时，差异具有统计学意义，但当将 CP 组与 MI 组进行比较时，差异无统计学意义。比较健康组和 CP 组以及 CP 组和 MI 组之间的血脂谱水平具有统计学意义。
与健康患者相比，CP 患者的内皮功能受损，根据 FMD 值观察到的功能障碍与 MI 组相似。
