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使用高度多孔钛杯进行全髋关节置换术后髋臼周围骨密度测定:一项为期2年的随访前瞻性研究。

Periacetabular bone densitometry after total hip arthroplasty with highly porous titanium cups: a 2-year follow-up prospective study.

作者信息

Massari Leo, Bistolfi Alessandro, Grillo Pier Paolo, Borré Alda, Gigliofiorito Gaetano, Pari Carlotta, Francescotto Andrea, Tosco Piermario, Deledda Davide, Ravera Laura, Causero Araldo

机构信息

University Hospital of Ferrara "S. Anna", Ferrara - Italy.

Department of Orthopaedics, Traumatology and Rehabilitation, Clinic II, University Hospital of Turin "Città della Salute e della Scienza di Torino", Turin - Italy.

出版信息

Hip Int. 2017 Nov 21;27(6):551-557. doi: 10.5301/hipint.5000509. Epub 2017 Jul 1.

Abstract

INTRODUCTION

Trabecular Titanium is an advanced cellular solid structure, composed of regular multiplanar hexagonal interconnected cells that mimic the morphology of the trabecular bone. This biomaterial demonstrated improved mechanical properties and enhanced osteoinduction and osteoconduction in several in vitro and in vivo studies. The aim of this study was to assess Trabecular Titanium osseointegration by measuring periacetabular changes in bone mineral density (BMD) with dual-emission X-ray absorptiometry (DEXA).

METHODS

89 patients (91 hips) underwent primary total hip arthroplasty (THA) with acetabular Trabecular Titanium cups. Clinical (Harris Hip Score (HHS), SF-36) and radiographic assessment were performed preoperatively, and postoperatively at 7 days and at 3, 6, 12 and 24 months. DEXA analysis was performed only postoperatively, using the BMD values measured at 7 days as baselines.

RESULTS

After an initial decrease from baseline to 6 months, BMD increased and progressively stabilised in all 3 regions of interest (ROIs). Median (IQR) HHS and SF-36 increased from 48 (39-62) and 49 (37-62) preoperatively to 99 (96-100) and 86 (79-92) at 24 months, indicating a considerable improvement in terms of pain relief, functional recovery and quality of life. BMD patterns and radiographic evaluation showed evident signs of periacetabular bone remodelling and osseointegration; all cups were stable at the final follow-up without radiolucent lines, loosening or osteolysis. No revisions were performed.

CONCLUSIONS

After an initial reduction in periacetabular BMD, all 3 ROIs exhibited stabilisation or slight recovery. Although clinical outcomes and functional recovery proved satisfactory, longer follow-ups are necessary to assess this cup long-term survivorship.

摘要

引言

小梁钛是一种先进的多孔固体结构,由规则的多平面六边形相互连接的单元组成,模拟小梁骨的形态。在多项体外和体内研究中,这种生物材料表现出改善的力学性能以及增强的骨诱导和骨传导能力。本研究的目的是通过双能X线吸收法(DEXA)测量髋臼周围骨密度(BMD)的变化来评估小梁钛的骨整合情况。

方法

89例患者(91髋)接受了使用髋臼小梁钛杯的初次全髋关节置换术(THA)。术前、术后7天以及术后3、6、12和24个月进行临床(Harris髋关节评分(HHS)、SF-36)和影像学评估。仅在术后进行DEXA分析,以术后7天测量的BMD值作为基线。

结果

从基线到6个月,所有感兴趣区域(ROIs)的BMD最初下降,随后增加并逐渐稳定。HHS和SF-36的中位数(IQR)从术前的48(39-62)和49(37-62)增加到24个月时的99(96-100)和86(79-92),表明在疼痛缓解、功能恢复和生活质量方面有显著改善。BMD模式和影像学评估显示髋臼周围骨重塑和骨整合的明显迹象;所有髋臼杯在最终随访时稳定,无透亮线、松动或骨溶解。未进行翻修手术。

结论

髋臼周围BMD最初下降后,所有3个ROIs均表现出稳定或轻微恢复。尽管临床结果和功能恢复令人满意,但需要更长时间的随访来评估这种髋臼杯的长期生存率。

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