Division of Transplantation and Mucosal Biology, King's College London, London, UK.
Semin Nephrol. 2017 Jul;37(4):362-369. doi: 10.1016/j.semnephrol.2017.05.008.
Women with diabetic nephropathy have challenging pregnancies, with pregnancy outcomes far worse than expected for the stage of chronic kidney disease. The underlying mechanisms that cause the adverse events remain poorly understood, but it is a widely held belief that substantial endothelial injury in these women likely contributes. Maternal hypertension, preeclampsia, and cesarean section rates are high, and offspring are often preterm and of low birth weight, with additional neonatal complications associated with glycemic control. This review will present the current evidence for maternal and fetal outcomes of women with diabetic nephropathy and describe prepregnancy, antenatal, and peripartum optimization strategies.
患有糖尿病肾病的女性妊娠面临诸多挑战，其妊娠结局远比慢性肾脏病阶段所预期的要差得多。导致不良事件的潜在机制仍知之甚少，但人们普遍认为这些女性的内皮损伤很可能是导致不良事件的原因。产妇高血压、子痫前期和剖宫产率都很高，婴儿往往早产且体重低，与血糖控制相关的还有其他新生儿并发症。本文将介绍目前关于糖尿病肾病女性的母婴结局的证据，并描述孕前、产前和围产期的优化策略。
