Cetin Mehmet Serkan, Ozcan Cetin Elif Hande, Akdi Ahmet, Aras Dursun, Topaloglu Serkan, Temizhan Ahmet, Aydogdu Sinan
Cardiology Department, Türkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
Kardiol Pol. 2017;75(10):1005-1012. doi: 10.5603/KP.a2017.0135. Epub 2017 Jul 17.
Platelets play a central role in myocardial infarction, and platelet activity can be evaluated with platelet indices, including platelet distribution width (PDW) and plateletcrit (PCT). These indices have been demonstrated as markers of prothrombotic state in cardiovascular diseases.
Therefore, we aimed to investigate, the usefulness of these biomarkers in ST-elevation myocardial infarction (STEMI) in young patients.
This cross-sectional study consisted of 565 subjects who were classified into three groups: group 1 (168 young patients with STEMI), group 2 (173 non-young patients with STEMI), and group 3 (224 age-matched controls with angiographically normal coronary arteries). Male patients aged under 45 years and female patients aged under 55 years were defined as young STEMI.
In group 1, PDW and PCT (17.2 ± 0.67, 0.249 ± 0.05, respectively) were significantly higher than the other groups (group 2, 16.4 ± 0.56, 0.231 ± 0.04; group 3, 15.1 ± 0.63, 0.227 ± 0.04). PDW and PCT had moderate negative correlation (r = -0.305, r = -0.330, respectively) with age and moderate positive correlation with peak creatine kinase MB (r = 0.259, r = 0.320, respectively). At multivariate analysis, adjusted for other factors, 1 fL increase in PDW levels was 13.5% more likely to be associated with young STEMI, and similarly, a 1% increase in PCT levels was 18.9% more likely associated with young STEMI.
Platelet distribution width and plateletcrit levels seem to be independent markers of STEMI in young patients and may reflect prothrombotic state in this specific population.
血小板在心肌梗死中起核心作用，血小板活性可通过血小板指标进行评估，包括血小板分布宽度（PDW）和血小板压积（PCT）。这些指标已被证明是心血管疾病中血栓前状态的标志物。
因此，我们旨在研究这些生物标志物在年轻患者ST段抬高型心肌梗死（STEMI）中的应用价值。
这项横断面研究纳入了565名受试者，分为三组：第1组（168例年轻STEMI患者）、第2组（173例非年轻STEMI患者）和第3组（224例年龄匹配的冠状动脉造影正常的对照者）。年龄在45岁以下的男性患者和55岁以下的女性患者被定义为年轻STEMI患者。
在第1组中，PDW和PCT（分别为17.2±0.67、0.249±0.05）显著高于其他组（第2组，16.4±0.56、0.231±0.04；第3组，15.1±0.63、0.227±0.04）。PDW和PCT与年龄呈中度负相关（分别为r=-0.305、r=-0.330），与肌酸激酶同工酶峰值呈中度正相关（分别为r=0.259、r=0.320）。在多因素分析中，在调整其他因素后，PDW水平每增加1 fL与年轻STEMI相关的可能性增加13.5%，同样，PCT水平每增加1%与年轻STEMI相关的可能性增加18.9%。
血小板分布宽度和血小板压积水平似乎是年轻患者STEMI的独立标志物，可能反映了这一特定人群的血栓前状态。
