Labrousse-Arias David, Martínez-Ruiz Antonio, Calzada María J
1 Servicio de Inmunología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP) , Madrid, Spain .
2 Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV) , Madrid, Spain .
Antioxid Redox Signal. 2017 Oct 20;27(12):802-822. doi: 10.1089/ars.2017.7275. Epub 2017 Sep 6.
The extracellular matrix (ECM) is an essential modulator of cell behavior that influences tissue organization. It has a strong relevance in homeostasis and translational implications for human disease. In addition to ECM structural proteins, matricellular proteins are important regulators of the ECM that are involved in a myriad of different pathologies. Recent Advances: Biochemical studies, animal models, and study of human diseases have contributed to the knowledge of molecular mechanisms involved in remodeling of the ECM, both in homeostasis and disease. Some of them might help in the development of new therapeutic strategies. This review aims to review what is known about some of the most studied matricellular proteins and their regulation by hypoxia and redox signaling, as well as the pathological implications of such regulation.
Matricellular proteins have complex regulatory functions and are modulated by hypoxia and redox signaling through diverse mechanisms, in some cases with controversial effects that can be cell or tissue specific and context dependent. Therefore, a better understanding of these regulatory processes would be of great benefit and will open new avenues of considerable therapeutic potential.
Characterizing the specific molecular mechanisms that modulate matricellular proteins in pathological processes that involve hypoxia and redox signaling warrants additional consideration to harness the potential therapeutic value of these regulatory proteins. Antioxid. Redox Signal. 27, 802-822.
细胞外基质（ECM）是影响组织构成的细胞行为的重要调节因子。它在体内平衡中具有重要意义，并对人类疾病具有转化意义。除了ECM结构蛋白外，基质细胞蛋白是ECM的重要调节因子，参与多种不同的病理过程。
生化研究、动物模型和人类疾病研究有助于了解ECM在体内平衡和疾病状态下重塑所涉及的分子机制。其中一些机制可能有助于开发新的治疗策略。本综述旨在回顾一些研究最多的基质细胞蛋白及其受缺氧和氧化还原信号调节的相关知识，以及这种调节的病理意义。
基质细胞蛋白具有复杂的调节功能，并且通过多种机制受到缺氧和氧化还原信号的调节，在某些情况下，其影响存在争议，可能具有细胞或组织特异性且取决于具体情况。因此，更好地理解这些调节过程将大有裨益，并将开辟具有巨大治疗潜力的新途径。
确定在涉及缺氧和氧化还原信号的病理过程中调节基质细胞蛋白的具体分子机制，值得进一步研究，以利用这些调节蛋白的潜在治疗价值。《抗氧化与氧化还原信号》27卷，802 - 822页。
