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丝状血凝素和百日咳毒素促进百日咳博德特氏菌黏附于纤毛。

Filamentous hemagglutinin and pertussis toxin promote adherence of Bordetella pertussis to cilia.

作者信息

Tuomanen E, Weiss A, Rich R, Zak F, Zak O

出版信息

Dev Biol Stand. 1985;61:197-204.

PMID:2872105
Abstract

Bordetella pertussis adheres specifically to the cilia of respiratory epithelial cells. This ability to adhere is characteristic of virulent organisms. In order to define the contribution of various virulence factors of B. pertussis to the process of adherence, mutants deficient in single virulence factors were tested for the ability to adhere to rabbit cilia in vitro and in vivo. Two protective antigens were found to be critical to the process of adherence: filamentous hemagglutinin and pertussis toxin.

摘要

百日咳博德特氏菌特异性地黏附于呼吸道上皮细胞的纤毛。这种黏附能力是有毒力的生物体的特征。为了确定百日咳博德特氏菌的各种毒力因子对黏附过程的作用，对缺乏单一毒力因子的突变体进行了体外和体内黏附兔纤毛能力的测试。发现两种保护性抗原对黏附过程至关重要：丝状血凝素和百日咳毒素。

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Filamentous hemagglutinin and pertussis toxin promote adherence of Bordetella pertussis to cilia.丝状血凝素和百日咳毒素促进百日咳博德特氏菌黏附于纤毛。
Dev Biol Stand. 1985;61:197-204.
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