Strompfová Viola, Kubašová Ivana, Lauková Andrea
Institute of Animal Physiology Slovak Academy of Sciences, Šoltésovej 4-6, 040 01, Košice, Slovakia.
Appl Microbiol Biotechnol. 2017 Aug;101(16):6309-6319. doi: 10.1007/s00253-017-8425-z. Epub 2017 Jul 18.
The importance of the intestinal microbiota has attracted much interest in recent years particularly with respect to ways in which the microbiota can be manipulated in order to improve health. Improving gut health through the use of probiotic microorganisms has become an area of research activity in both human and animal nutrition. However, the amount of research using companion animals is insufficient. The present review evaluates and compares the effects achieved after application of canine-derived probiotic strain Lactobacillus fermentum CCM 7421 to healthy dogs as well as to dogs suffering from gastrointestinal disorders. The experiments involved varying duration of application (4 days-14 days), dosage (10-10 CFU), form of application (fresh culture or lyophilized from) or combination with natural substances. Results from nine independent studies show the ability of probiotic strains to establish themselves in the canine gastrointestinal tract, alter the composition of intestinal microbiota and metabolites (organic acids), and modulate the physiology (serum biochemical parameters) and immunity parameters in dogs. Almost all observed effects were irrespective of dose or duration of probiotic administration.
近年来，肠道微生物群的重要性引起了人们的广泛关注，尤其是在如何通过操控微生物群来改善健康方面。通过使用益生菌微生物来改善肠道健康已成为人类和动物营养领域的一个研究热点。然而，针对伴侣动物的相关研究数量不足。本综述评估并比较了将犬源益生菌发酵乳杆菌CCM 7421应用于健康犬以及患有胃肠道疾病的犬后所取得的效果。实验涉及不同的应用持续时间（4天至14天）、剂量（10⁸ - 10¹⁰CFU）、应用形式（新鲜培养物或冻干物）或与天然物质的组合。九项独立研究的结果表明，益生菌菌株能够在犬的胃肠道中定殖，改变肠道微生物群和代谢物（有机酸）的组成，并调节犬的生理（血清生化参数）和免疫参数。几乎所有观察到的效果都与益生菌给药的剂量或持续时间无关。
