Centro de Referencia para Lactobacilos (CERELA), CONICET, Chacabuco 145, (T4000) Tucumán, Argentina (Molina, Miranda, Maldonado, Vignolo, Nader-Macías); Facultad de Agronomía y Zootecnia (Molina) and Cátedra de Bioestadística, Facultad de Medicina (D'Urso Villar), Universidad Nacional de Tucumán (UNT), (T4000) Tucumán, Argentina.
Can Vet J. 2023 Jul;64(7):666-673.
Acute diarrhea is among the most common causes of veterinary consultations for dogs. A double-blind, placebocontrolled intervention trial was done with 120 puppies with gastroenteritis. These dogs were 1 to 4 mo old, male and female, of various breeds and sizes.
Dogs were randomly allocated into 2 groups: Those in the treated group (TG) received a multi-strain probiotic with CRL1693, CRL1695, CRL1696, and CRL1702 (1 × 10 CFU/mL) daily for 7 d, whereas those in the control group (CG) received a placebo. All puppies received intravenous fluids, an antiparasitic, amoxicillin PO, and enrofloxacin SC.
At the start of the trial, the 2 groups were similar. Probiotic administration for 7 d normalized fecal consistency, with 69, 50, and 80% of small, medium, and large puppies in the TG achieving a fecal score of 1 (separate hard lumps) at 7 d, significantly better than puppies in the CG. After 7 d of treatment, most puppies (70%) in the TG had an excellent recovery, whereas in the CG, recoveries were 35.7% "bad" and 30.4% "fair." Therefore, treatment with probiotics hastened recovery ( < 0.0001). At the end of the trial, there was a significant increase of cultivable lactobacilli in the feces of TG puppies, but no significant differences between the 2 groups in numbers of total mesophylls, enterobacteria, or Gram-positive cocci. Total mortality was 5.8%, including 4 puppies from the CG and 3 from the TG.
In a randomized, double-blind, placebo-controlled study, puppies with gastroenteritis symptoms receiving a multi-strain probiotic had rapid improvement, implying beneficial effects on the microbiota and its functionality.
急性腹泻是犬类兽医咨询最常见的原因之一。我们对 120 只有肠胃炎的幼犬进行了一项双盲、安慰剂对照的干预试验。这些狗 1 至 4 月龄，公母，不同品种和大小。
狗被随机分配到 2 组：治疗组（TG）每天接受含有 CRL1693、CRL1695、CRL1696 和 CRL1702（1×10 CFU/mL）的多菌株益生菌，持续 7 天，而对照组（CG）接受安慰剂。所有幼犬均接受静脉输液、驱虫、口服阿莫西林和恩诺沙星 SC。
在试验开始时，两组相似。益生菌治疗 7 天可使粪便稠度正常，TG 中小、中、大幼犬中有 69%、50%和 80%在第 7 天粪便评分达到 1（单独的硬粪块），明显优于 CG 中的幼犬。治疗 7 天后，TG 中的大多数幼犬（70%）恢复良好，而 CG 中的恢复情况分别为 35.7%“差”和 30.4%“一般”。因此，益生菌治疗可加快恢复（<0.0001）。试验结束时，TG 幼犬粪便中可培养的乳杆菌数量显著增加，但两组之间的总肠细胞、肠杆菌和革兰氏阳性球菌数量无显著差异。总死亡率为 5.8%，包括 CG 中的 4 只幼犬和 TG 中的 3 只幼犬。
在一项随机、双盲、安慰剂对照研究中，患有肠胃炎症状的幼犬接受多菌株益生菌治疗后迅速改善，这表明对微生物群及其功能有有益的影响。
