核糖体针对自身催化生产进行了优化。
Ribosomes are optimized for autocatalytic production.
作者信息
Reuveni Shlomi, Ehrenberg Måns, Paulsson Johan
机构信息
Department of Systems Biology, HMS, Harvard University, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.
Department of Cell and Molecular Biology, Uppsala University, Uppsala Biomedicinska Centrum (BMC) Husargatan 3, Uppsala, Sweden.
出版信息
Nature. 2017 Jul 19;547(7663):293-297. doi: 10.1038/nature22998.
Abstract
Many fine-scale features of ribosomes have been explained in terms of function, revealing a molecular machine that is optimized for error-correction, speed and control. Here we demonstrate mathematically that many less well understood, larger-scale features of ribosomes-such as why a few ribosomal RNA molecules dominate the mass and why the ribosomal protein content is divided into 55-80 small, similarly sized segments-speed up their autocatalytic production.
摘要
核糖体的许多精细尺度特征已根据功能得到解释，揭示出一种为纠错、速度和控制而优化的分子机器。在此，我们通过数学证明，核糖体的许多较难理解的更大尺度特征——比如为何少数核糖体RNA分子占质量主导地位，以及为何核糖体蛋白质含量被分为55 - 80个大小相近的小片段——会加速其自身催化生成。
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