Chiaruttini Nicolas, Roux Aurélien
Department of Biochemistry, University of Geneva, CH-1211 Geneva, Switzerland.
Department of Biochemistry, University of Geneva, CH-1211 Geneva, Switzerland; Swiss National Centre for Competence in Research Programme Chemical Biology, CH-1211 Geneva, Switzerland.
Curr Opin Cell Biol. 2017 Aug;47:126-135. doi: 10.1016/j.ceb.2017.07.002. Epub 2017 Jul 17.
The ESCRT-III complex is an evolutionary ancient and conserved complex that catalyzes fission of lipid membranes from the lumen of the neck in many, if not all processes requiring this specific fission reaction. The ESCRT-III membrane remodeling complex is unique as its molecular and polymeric structures do not intuitively suggests how it could deform and break lipid membranes. Here we review the common structural features of the ESCRT-III subunits, and the shape diversity of the various filamentous forms. We propose a simple geometry and elasticity framework that could help to isolate which features of the ESCRT-III filaments are common to all filamentous forms as well as to explain their diversity. We speculate on how these features could provide mechanistic insights into the many functions of the ESCRT-III complex.
内体分选转运复合体III（ESCRT-III）是一种在进化上古老且保守的复合体，在许多（即便不是所有）需要这种特定裂变反应的过程中，它催化颈部管腔处脂膜的裂变。ESCRT-III膜重塑复合体很独特，因为其分子结构和聚合结构并未直观地表明它如何使脂膜变形和破裂。在此，我们综述了ESCRT-III亚基的共同结构特征，以及各种丝状形式的形状多样性。我们提出了一个简单的几何和弹性框架，这有助于确定ESCRT-III细丝的哪些特征是所有丝状形式共有的，同时也有助于解释它们的多样性。我们推测这些特征如何能为ESCRT-III复合体的多种功能提供机制上的见解。
