赌博成瘾者纹状体多巴胺合成能力增加。
Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction.
机构信息
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands; Department of Psychiatry, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands.
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
出版信息
Biol Psychiatry. 2018 Jun 15;83(12):1036-1043. doi: 10.1016/j.biopsych.2017.06.010. Epub 2017 Jun 16.
BACKGROUND
The hypothesis that dopamine plays an important role in the pathophysiology of pathological gambling is pervasive. However, there is little to no direct evidence for a categorical difference between pathological gamblers and healthy control subjects in terms of dopamine transmission in a drug-free state. Here we provide evidence for this hypothesis by comparing dopamine synthesis capacity in the dorsal and ventral parts of the striatum in 13 pathological gamblers and 15 healthy control subjects.
METHODS
This was achieved using [F]fluoro-levo-dihydroxyphenylalanine dynamic positron emission tomography scans and striatal regions of interest that were hand-drawn based on visual inspection of individual structural magnetic resonance imaging scans.
RESULTS
Our results show that dopamine synthesis capacity was increased in pathological gamblers compared with healthy control subjects. Dopamine synthesis was 16% higher in the caudate body, 17% higher in the dorsal putamen, and 17% higher in the ventral striatum in pathological gamblers compared with control subjects. Moreover, dopamine synthesis capacity in the dorsal putamen and caudate head was positively correlated with gambling distortions in pathological gamblers.
CONCLUSIONS
Taken together, these results provide empirical evidence for increased striatal dopamine synthesis in pathological gambling.
背景
多巴胺在病理性赌博的病理生理学中起着重要作用，这一假说已经得到广泛认可。然而，在药物戒断状态下，病理性赌博者和健康对照组之间的多巴胺传递是否存在明确的分类差异，几乎没有直接证据。通过比较 13 名病理性赌博者和 15 名健康对照组纹状体背侧和腹侧部位的多巴胺合成能力，我们为这一假说提供了证据。
方法
这是通过使用[F]氟代左旋二羟苯丙氨酸动态正电子发射断层扫描和基于个体结构磁共振成像扫描的视觉检查手工绘制的纹状体感兴趣区来实现的。
结果
我们的结果表明，与健康对照组相比，病理性赌博者的多巴胺合成能力增加。与对照组相比，病理性赌博者的尾状核体多巴胺合成增加了 16%，背侧壳核增加了 17%，腹侧纹状体增加了 17%。此外，背侧壳核和尾状核头部的多巴胺合成能力与病理性赌博者的赌博扭曲呈正相关。
结论
综上所述，这些结果为病理性赌博中纹状体多巴胺合成增加提供了经验证据。
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