Tran Van Nam, Truong Van Gia, Jeong Seok, Kang Hyun Wook
Interdisciplinary Program of Marine-Bio, Electrical & Mechanical Engineering, Pukyong National University, Busan, South Korea.
Division of Gastroenterology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea.
Biomed Opt Express. 2018 May 9;9(6):2575-2587. doi: 10.1364/BOE.9.002575. eCollection 2018 Jun 1.
Accurate treatment planning and monitoring are critical factors to ensure safe and effective outcomes of laser thermal coagulation (LTC). Computational and experimental models based upon linear energy modulation were deployed to predict temperature distribution and thermal damage within porcine liver. 1470-nm Gaussian emission was confirmed by using digital imaging and the customized goniometry. The tissue temperature was maintained in the pre-determined range (65~75 °C) to induce thermally destructive volumes of 0.23 cm (simulation) and 0.17 ± 0.05 cm (experiment) once the applied power was linearly reduced from 3.5 W to 0.2 W in 50 s ("3.5 W fast slope" laser modulation mode). The proposed model may be a useful tool to predict thermal responses of the tissue during LTC.
精确的治疗规划和监测是确保激光热凝术（LTC）安全有效结果的关键因素。基于线性能量调制的计算模型和实验模型被用于预测猪肝内的温度分布和热损伤。通过数字成像和定制测角术确认了1470纳米高斯发射。一旦在50秒内将施加功率从3.5瓦线性降低至0.2瓦（“3.5瓦快速斜率”激光调制模式），组织温度维持在预定范围内（65~75°C），以诱导出模拟热破坏体积为0.23立方厘米，实验热破坏体积为0.17±0.05立方厘米。所提出的模型可能是预测LTC期间组织热响应的有用工具。
