光能调制对生物组织热响应的影响：计算与实验验证
Effect of optical energy modulation on the thermal response of biological tissue: computational and experimental validations.
作者信息
Tran Van Nam, Truong Van Gia, Lee Yong Wook, Kang Hyun Wook
机构信息
Interdisciplinary Program of Marine-Bio, Electrical & Mechanical Engineering, Pukyong National University, Busan, Republic of Korea.
School of Electrical Engineering, Pukyong National University, Busan, Republic of Korea.
出版信息
Biomed Opt Express. 2020 Nov 4;11(12):6905-6919. doi: 10.1364/BOE.404827. eCollection 2020 Dec 1.
Abstract
This study develops an energy modulation technique to attain a constant interstitial tissue temperature and to induce the predetermined thermal coagulation without carbonization in tissue. An optical diffuser was employed to deliver 1064 nm light to the biological tissue. The combined mode maintained the interstitial temperature at 70 °C for longer durations compared to the continuous wave mode. Coagulation volumes increased linearly with the time and met the predetermined treatment volume range (0.32-0.52 cm) after the combined treatment for 100 s. The combined modulation can be a feasible modality to induce the predetermined extent of thermal coagulation for treating papillary thyroid microcarcinoma.
摘要
本研究开发了一种能量调制技术，以实现恒定的组织间温度，并在组织中诱导预定的热凝固而不碳化。采用光学漫射器将1064 nm光传输到生物组织。与连续波模式相比，组合模式能将组织间温度维持在70°C更长时间。凝固体积随时间呈线性增加，在组合治疗100秒后达到预定的治疗体积范围（0.32 - 0.52厘米）。组合调制可能是一种可行的方式，用于诱导预定程度的热凝固以治疗甲状腺微小乳头状癌。
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