Waziri R, Mott J
Psychiatry Res. 1986 Jun;18(2):119-26. doi: 10.1016/0165-1781(86)90024-7.
The question of whether neuroleptics can play a role in the hyperserinemia and low serine hydroxymethyltransferase (SHMT) activity previously reported in psychotic patients is investigated in this report. We find that in drug-free psychotics who had significantly higher plasma serine levels (PSL) and lower SHMT activity compared to nonpsychotics and normal subjects, more than 2 weeks of neuroleptic treatment decreased PSL and did not affect SHMT activity. This finding makes it unlikely that neuroleptics play an important role in the hyperserinemia of psychotics. The possible role of dietary factors in these patients is also discussed.
本报告研究了抗精神病药物是否能在先前报道的精神病患者高血清素血症和低丝氨酸羟甲基转移酶（SHMT）活性中发挥作用的问题。我们发现，与非精神病患者和正常受试者相比，未服用药物的精神病患者血浆丝氨酸水平（PSL）显著更高且SHMT活性更低，超过2周的抗精神病药物治疗可降低PSL，但不影响SHMT活性。这一发现表明抗精神病药物不太可能在精神病患者的高血清素血症中起重要作用。还讨论了饮食因素在这些患者中的可能作用。
