Harold Simmons Center for Chronic Disease Research and Epidemiology, University of California Irvine, School of Medicine, 101 The City Drive South, City Tower, Suite 400, Orange, California 92868, USA.
Harold Simmons Center for Chronic Disease Research and Epidemiology, University of California Irvine, School of Medicine, 101 The City Drive South, City Tower, Suite 400, Orange, California 92868, USA; and at the Tibor Rubin Veterans Affairs Medical Center, 5901 E 7 th Street, Long Beach, California 90822, USA.
Nat Rev Nephrol. 2017 Sep;13(9):521-522. doi: 10.1038/nrneph.2017.105. Epub 2017 Jul 24.
Debate exists regarding the safety of metformin and the risk of metformin-associated lactic acidosis, particularly in the setting of kidney dysfunction. Data from two studies examining the interplay between metformin, acute kidney injury, and complications including lactic acidosis suggest that metformin should be used conservatively in patients with kidney dysfunction.
关于二甲双胍的安全性和乳酸酸中毒风险存在争议，特别是在肾功能不全的情况下。两项研究的数据检查了二甲双胍、急性肾损伤以及包括乳酸酸中毒在内的并发症之间的相互作用，表明肾功能不全的患者应谨慎使用二甲双胍。
