Rink Cameron L, Wernke Matthew M, Powell Heather M, Tornero Mark, Gnyawali Surya C, Schroeder Ryan M, Kim Jayne Y, Denune Jeffrey A, Albury Alexander W, Gordillo Gayle M, Colvin James M, Sen Chandan K
Department of Surgery, Comprehensive Wound Center and Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio.
The Ohio Willow Wood Company, Mt. Sterling, Ohio.
Adv Wound Care (New Rochelle). 2017 Jul 1;6(7):225-232. doi: 10.1089/wound.2017.0737.
(1) Develop a standardized approach to quantitatively measure residual limb skin health. (2) Report reference residual limb skin health values in people with transtibial and transfemoral amputation. Residual limb health outcomes in individuals with transtibial ( = 5) and transfemoral ( = 5) amputation were compared to able-limb controls ( = 4) using noninvasive imaging (hyperspectral imaging and laser speckle flowmetry) and probe-based approaches (laser doppler flowmetry, transcutaneous oxygen, transepidermal water loss, surface electrical capacitance). A standardized methodology that employs noninvasive imaging and probe-based approaches to measure residual limb skin health are described. Compared to able-limb controls, individuals with transtibial and transfemoral amputation have significantly lower transcutaneous oxygen tension, higher transepidermal water loss, and higher surface electrical capacitance in the residual limb. Residual limb health as a critical component of prosthesis rehabilitation for individuals with lower limb amputation is understudied in part due to a lack of clinical measures. Here, we present a standardized approach to measure residual limb health in people with transtibial and transfemoral amputation. Technology advances in noninvasive imaging and probe-based measures are leveraged to develop a standardized approach to quantitatively measure residual limb health in individuals with lower limb loss. Compared to able-limb controls, resting residual limb physiology in people that have had transfemoral or transtibial amputation is characterized by lower transcutaneous oxygen tension and poorer skin barrier function.
(1) 开发一种标准化方法来定量测量残肢皮肤健康状况。(2) 报告经胫截肢和经股截肢患者的残肢皮肤健康参考值。使用非侵入性成像（高光谱成像和激光散斑血流仪）和基于探头的方法（激光多普勒血流仪、经皮氧分压、经表皮水分流失、表面电容），将经胫截肢（n = 5）和经股截肢（n = 5）个体的残肢健康结果与健全肢体对照组（n = 4）进行比较。描述了一种采用非侵入性成像和基于探头的方法来测量残肢皮肤健康的标准化方法。与健全肢体对照组相比，经胫截肢和经股截肢个体的残肢经皮氧分压显著降低，经表皮水分流失更高，表面电容更高。残肢健康作为下肢截肢患者假肢康复的关键组成部分，部分由于缺乏临床测量方法而未得到充分研究。在此，我们提出一种标准化方法来测量经胫截肢和经股截肢患者的残肢健康状况。利用非侵入性成像和基于探头测量的技术进步，开发一种标准化方法来定量测量下肢缺失个体的残肢健康状况。与健全肢体对照组相比，经股截肢或经胫截肢患者静息时的残肢生理特征是经皮氧分压较低且皮肤屏障功能较差。
