Higuchi Yuko, Sumiyoshi Tomiki, Seo Tomonori, Suga Motomu, Takahashi Tsutomu, Nishiyama Shimako, Komori Yuko, Kasai Kiyoto, Suzuki Michio
Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Japan.
Schizophr Res Cogn. 2017 Feb 22;7:13-18. doi: 10.1016/j.scog.2017.01.001. eCollection 2017 Mar.
Cognitive function is impaired in patients with schizophrenia-spectrum disorders, even in their prodromal stages. Specifically, the assessment of cognitive abilities related to daily-living functioning, or functional capacity, is important to predict long-term outcome. In this study, we sought to determine the validity of the Schizophrenia Cognition Rating Scale (SCoRS) Japanese version, an interview-based measure of cognition relevant to functional capacity (i.e. co-primary measure). For this purpose, we examined the relationship of SCoRS scores with performance on the Brief Assessment of Cognition in Schizophrenia (BACS) Japanese version, a standard neuropsychological test battery, and the Social and Occupational Functioning Assessment Scale (SOFAS), an interview-based social function scale. Subjects for this study (n = 294) included 38 patients with first episode schizophrenia (FES), 135 with chronic schizophrenia (CS), 102 with at-risk mental state (ARMS) and 19 with other psychiatric disorders with psychosis. SCoRS scores showed a significant relationship with SOFAS scores for the entire subjects. Also, performance on the BACS was significantly correlated with SCoRS scores. These associations were also noted within each diagnosis (FES, CS, ARMS). These results indicate the utility of SCoRS as a measure of functional capacity that is associated both with cognitive function and real-world functional outcome in subjects with schizophrenia-spectrum disorders.
精神分裂症谱系障碍患者即使在前驱期认知功能也会受损。具体而言，评估与日常生活功能或功能能力相关的认知能力对于预测长期预后很重要。在本研究中，我们试图确定精神分裂症认知评定量表（SCoRS）日语版的有效性，这是一种基于访谈的与功能能力相关的认知测量方法（即共同主要测量方法）。为此，我们研究了SCoRS分数与精神分裂症认知简短评估（BACS）日语版（一种标准神经心理测试组合）的表现以及社会和职业功能评估量表（SOFAS）（一种基于访谈的社会功能量表）之间的关系。本研究的受试者（n = 294）包括38例首发精神分裂症（FES）患者、135例慢性精神分裂症（CS）患者、102例有精神病风险状态（ARMS）患者和19例患有其他伴有精神病性症状的精神障碍患者。对于所有受试者，SCoRS分数与SOFAS分数显示出显著关系。此外，BACS的表现与SCoRS分数显著相关。在每个诊断组（FES、CS、ARMS）中也观察到了这些关联。这些结果表明SCoRS作为一种功能能力测量方法的效用，它与精神分裂症谱系障碍患者的认知功能和现实世界功能结局均相关。
