Liu Shi-Wei, Guo Jie, Wu Wei-Kang, Chen Ze-Liang, Zhang Ning
Department of Nephrology and Endocrinology, Wangjing Hospital, Chinese Academy of Chinese Medical Science, Beijing, 100102, China.
Institute of Integrative Medicine, Sun Yat-sen University, Guangzhou, 510275, China.
Chin J Integr Med. 2019 Jan;25(1):16-22. doi: 10.1007/s11655-017-2960-4. Epub 2017 Jul 25.
To evaluate Chinese medicine (CM) formula Bazheng Powder () as an alternative therapeutic option for female patients with recurrent urinary tract infection (RUTI).
A randomized double-blinded trial was performed. Eligible female patients with RUTI were recruited from one hospital and two community health centers. By using a blocked randomization scheme, participants were randomized to receive a CM formula (10 herbs) for 4 weeks or antibiotics for 1 week, followed by 3 weeks of placebo. Clinical cure rate and microbiological cure and recurrence after treatment were evaluated.
A total 122 eligible patients were enrolled, with 61 cases in each group. The clinical cure rate by the intentto- treatment approach was 90.2% for the CM group and 82.0% for the antibiotics group (P>0.05). Bacteria were cleared from 88.5% (54/61) of patients in the CM group and 82.0% (50/61) in the antibiotics group. The recurrence rate in recovered patients at the 6-month follow-up was 9.1% (5/61) and 14.0 (7/61) in the CM and antibiotics groups, respectively (P>0.05).
CM formula Bazheng Powder is a good alternative option for RUTI treatment. (Registration No. NCT01745328).
评估中药八正散作为复发性尿路感染（RUTI）女性患者的一种替代治疗选择。
进行了一项随机双盲试验。从一家医院和两个社区卫生中心招募符合条件的复发性尿路感染女性患者。采用区组随机化方案，将参与者随机分为接受中药配方（10味草药）治疗4周或抗生素治疗1周，随后3周服用安慰剂。评估治疗后的临床治愈率、微生物学治愈率和复发情况。
共纳入122例符合条件的患者，每组61例。按意向性治疗分析，中药组的临床治愈率为90.2%，抗生素组为82.0%（P>0.05）。中药组88.5%（54/61）的患者细菌清除，抗生素组为82.0%（50/61）。在6个月随访时，康复患者中中药组和抗生素组的复发率分别为9.1%（5/61）和14.0%（7/61）（P>0.05）。
中药八正散是复发性尿路感染治疗的一种良好替代选择。（注册号：NCT01745328）
