Abarikwu Sunny O, Duru Queen C, Njoku Rex-Clovis C, Amadi Benjamin A, Tamunoibuomie Aseme, Keboh Enebimoere
a Department of Biochemistry , University of Port Harcourt , Choba , Nigeria.
Ren Fail. 2017 Nov;39(1):588-596. doi: 10.1080/0886022X.2017.1351373.
Both ethanol (EtoH) and atrazine (ATZ) have hepatic and nephro-toxic effects in rats. In the present study, the toxicity of EtoH (5 g kg) on the kidney and liver in the absence or in the presence of different doses of ATZ (50, 100, 300 mg kg) was evaluated after 21 days in rats. Results showed that the mixture effects on catalase and superoxide dismutase activities were more severe in both tissues compared to EtoH alone, especially as the dose of ATZ was increased. Hepatic malondialdehyde level (an index of lipid peroxidation) was increased from 20.32% in the EtoH +50 mg kg ATZ-treated rats to 34% in the EtoH +300 mg kg ATZ-treated rats compared to the EtoH values. Renal malondialdehyde values remain as high as 81% in the EtoH-treated rats and the different combine exposure groups. Furthermore, as the dose of ATZ in the mixture was increased, serum uric acid level increased compared to the EtoH values. When the EtoH +300 mg kg ATZ-animals were pretreated with curcumin (an antioxidant), the histopathological changes and peroxidative damages in both tissues were blocked. The exposure of EtoH-treated rats to ATZ enhanced renal and hepatic peroxidative damages in rats.
乙醇（EtoH）和莠去津（ATZ）对大鼠均具有肝脏和肾脏毒性作用。在本研究中，对大鼠给予21天的乙醇（5 g/kg），评估在不存在或存在不同剂量莠去津（50、100、300 mg/kg）的情况下，乙醇对大鼠肾脏和肝脏的毒性。结果表明，与单独使用乙醇相比，两种组织中过氧化氢酶和超氧化物歧化酶活性的混合效应更为严重，尤其是随着莠去津剂量的增加。与乙醇组相比，肝丙二醛水平（脂质过氧化指标）在乙醇 + 50 mg/kg莠去津处理的大鼠中从20.32%增加到乙醇 + 300 mg/kg莠去津处理的大鼠中的34%。在乙醇处理的大鼠和不同联合暴露组中，肾丙二醛值高达81%。此外，与乙醇组相比，随着混合物中莠去津剂量的增加，血清尿酸水平升高。当用姜黄素（一种抗氧化剂）预处理乙醇 + 300 mg/kg莠去津组动物时，两种组织中的组织病理学变化和过氧化损伤均被阻断。乙醇处理的大鼠暴露于莠去津会增强大鼠肾脏和肝脏的过氧化损伤。
