Terterov Dimitry, Leung Philemon Ho-Yan, Twells Laurie K, Gregory Deborah M, Smith Chris, Boone Darrell, Pace David
From the Eastern Health Sciences Centre, St. John's, NL (Terterov, Leung, Boone, Pace); the Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL (Terterov, Leung, Twells, Gregory, Smith, Boone, Pace); and the School of Pharmacy, Memoral University of Newfoundland, St. John's, NL (Twells).
Can J Surg. 2017 Sep;60(5):335-341. doi: 10.1503/cjs.015216.
Although laparoscopic sleeve gastrectomy (LSG) has been shown to be a safe and effective treatment for severe obesity (body mass index ≥ 35), staple line leaks remain a major complication and account for a substantial portion of the procedure's morbidity and mortality. Many centres performing LSG routinely obtain contrast studies on postoperative day 1 for early detection of staple line leaks. We examined the usefulness of Gastrografin swallow as an early detection test for staple line leaks on postoperative day 1 after LSG as well as the associated costs.
We conducted a retrospective review of a prospectively collected database that included 200 patients who underwent LSG for severe obesity between 2011 and 2014. Primary outcome measures were the incidence of staple line leaks and the results of Gastrografin swallow tests. We obtained imaging costs from appropriate hospital departments.
Gastrografin swallow was obtained on postoperative day 1 for all 200 patients who underwent LSG. Three patients (1.5%) were found to have staple line leaks. Gastrograffin swallows yielded 1 true positive result and 2 false negatives. The false negatives were subsequently diagnosed on computed tomography (CT) scan. The sensitivity of Gastrografin swallow in this study was 33%. For 200 patients, the total direct cost of the Gastrografin swallows was $35 000.
The use of routine upper gastrointestinal contrast studies for early detection of staple line leaks has low sensitivity and is costly. We recommend selective use of CT instead.
尽管腹腔镜袖状胃切除术(LSG)已被证明是治疗重度肥胖(体重指数≥35)的一种安全有效的方法,但吻合口漏仍是一个主要并发症,占该手术发病率和死亡率的很大一部分。许多开展LSG的中心通常在术后第1天进行造影检查,以早期发现吻合口漏。我们研究了口服泛影葡胺作为LSG术后第1天吻合口漏早期检测试验的有效性以及相关成本。
我们对一个前瞻性收集的数据库进行了回顾性分析,该数据库包括2011年至2014年间因重度肥胖接受LSG的200例患者。主要观察指标为吻合口漏的发生率和口服泛影葡胺试验的结果。我们从医院相关科室获取了影像检查费用。
所有200例接受LSG的患者均在术后第1天进行了口服泛影葡胺检查。3例患者(1.5%)被发现有吻合口漏。口服泛影葡胺检查产生了1个真阳性结果和2个假阴性结果。假阴性结果随后通过计算机断层扫描(CT)确诊。本研究中口服泛影葡胺的敏感性为33%。对于200例患者,口服泛影葡胺的总直接费用为35000美元。
常规上消化道造影检查用于早期发现吻合口漏的敏感性较低且成本较高。我们建议选择性地使用CT检查替代。