镍催化的 9-BBN 硼酸酯的对映选择性串联交叉偶联。
Nickel-Catalyzed Enantioselective Conjunctive Cross-Coupling of 9-BBN Borates.
机构信息
Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA, 02467, USA.
出版信息
Angew Chem Int Ed Engl. 2017 Sep 18;56(39):11870-11874. doi: 10.1002/anie.201706719. Epub 2017 Aug 17.
Abstract
Catalytic enantioselective conjunctive cross-coupling between 9-BBN borate complexes and aryl electrophiles can be accomplished with Ni salts in the presence of a chiral diamine ligand. The reactions furnish chiral 9-BBN derivatives in an enantioselective fashion and these are converted to chiral alcohols and amines, or engaged in other stereospecific C-C bond forming reactions.
摘要
镍盐存在下，手性二胺配体可以催化硼酸 9-BBN 配合物与芳基亲电试剂的对映选择性偶联交叉偶联。这些反应以对映选择性的方式提供手性 9-BBN 衍生物，这些衍生物可以转化为手性醇和胺，或者参与其他立体特异性的 C-C 键形成反应。
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