将多胺代谢添加到细胞生长和癌症中的mTORC1工具包中。
Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer.
作者信息
Gomes Ana P, Schild Tanya, Blenis John
机构信息
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
出版信息
Dev Cell. 2017 Jul 24;42(2):112-114. doi: 10.1016/j.devcel.2017.07.004.
Abstract
The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is a major nutrient sensor and regulator of cellular metabolic flux. Reporting recently in Nature, Zabala-Letona et al. (2017) show that mTORC1 regulates an additional branch of metabolism in the cell-polyamine synthesis-that is important for prostate cancer tumorigenicity.
摘要
哺乳动物雷帕霉素靶蛋白复合物1（mTORC1）是细胞代谢通量的主要营养传感器和调节器。Zabala-Letona等人（2017年）最近在《自然》杂志上发表报告称，mTORC1调节细胞中另一个代谢分支——多胺合成，这对前列腺癌的肿瘤发生很重要。
相似文献
1
Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer.将多胺代谢添加到细胞生长和癌症中的mTORC1工具包中。
Dev Cell. 2017 Jul 24;42(2):112-114. doi: 10.1016/j.devcel.2017.07.004.
2
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.mTORC1依赖性的AMD1调节维持前列腺癌中的多胺代谢。
Nature. 2017 Jul 6;547(7661):109-113. doi: 10.1038/nature22964. Epub 2017 Jun 28.
3
mTORC1: turning off is just as important as turning on.mTORC1：关闭与开启同样重要。
Cell. 2014 Feb 13;156(4):627-8. doi: 10.1016/j.cell.2014.01.057.
4
Mechanistic target of rapamycin complex 1 is an essential mediator of metabolic and mitogenic effects of fibroblast growth factor 19 in hepatoma cells.雷帕霉素靶蛋白复合物 1 是成纤维细胞生长因子 19 在肝癌细胞中代谢和有丝分裂效应的重要介质。
Hepatology. 2016 Oct;64(4):1289-301. doi: 10.1002/hep.28639. Epub 2016 Jun 15.
5
Multiple amino acid sensing inputs to mTORC1.mTORC1的多种氨基酸感应输入
Cell Res. 2016 Jan;26(1):7-20. doi: 10.1038/cr.2015.146. Epub 2015 Dec 11.
6
mTORC1 regulates the efficiency and cellular capacity for protein synthesis.mTORC1 调节蛋白质合成的效率和细胞容量。
Biochem Soc Trans. 2013 Aug;41(4):923-6. doi: 10.1042/BST20130036.
7
Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: a tale of two complexes.多形性胶质母细胞瘤中mTORC1和mTORC2的不同信号传导机制：两种复合物的故事
Adv Biol Regul. 2015 Jan;57:64-74. doi: 10.1016/j.jbior.2014.09.004. Epub 2014 Sep 18.
8
Mammalian target of rapamycin and tuberous sclerosis complex.雷帕霉素哺乳动物靶点与结节性硬化症复合物
J Dermatol Sci. 2015 Aug;79(2):93-100. doi: 10.1016/j.jdermsci.2015.04.005. Epub 2015 Apr 25.
9
Phosphatase 2A puts the brakes on mTORC1 nutrient signaling.磷酸酶 2A 对 mTORC1 营养信号起刹车作用。
Cell Metab. 2010 Apr 7;11(4):245-7. doi: 10.1016/j.cmet.2010.03.011.
10
The molecular basis of mTORC1-regulated translation.mTORC1调节翻译的分子基础。
Biochem Soc Trans. 2017 Feb 8;45(1):213-221. doi: 10.1042/BST20160072.
引用本文的文献
1
Prognostic, oncogenic roles, and pharmacogenomic features of AMD1 in hepatocellular carcinoma.AMD1在肝细胞癌中的预后、致癌作用及药物基因组学特征
Cancer Cell Int. 2024 Dec 18;24(1):398. doi: 10.1186/s12935-024-03593-x.
2
Intestinal -derived small RNAs target porcine polyamine metabolism.肠道来源的小 RNA 靶向猪的多胺代谢。
Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2413241121. doi: 10.1073/pnas.2413241121. Epub 2024 Oct 3.
3
Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control.亚精胺-eIF5A轴通过翻译控制对肌肉干细胞激活至关重要。
Cell Discov. 2024 Sep 10;10(1):94. doi: 10.1038/s41421-024-00712-w.
4
Polyamines: their significance for maintaining health and contributing to diseases.多胺：维持健康和引发疾病的意义。
Cell Commun Signal. 2023 Dec 4;21(1):348. doi: 10.1186/s12964-023-01373-0.
5
One-Carbon and Polyamine Metabolism as Cancer Therapy Targets.一碳和多胺代谢作为癌症治疗靶点。
Biomolecules. 2022 Dec 19;12(12):1902. doi: 10.3390/biom12121902.
6
Characterization of nanoparticles combining polyamine detection with photodynamic therapy.结合聚胺检测与光动力疗法的纳米颗粒的特性研究。
Commun Biol. 2021 Jul 1;4(1):803. doi: 10.1038/s42003-021-02317-5.
7
Muscle transcriptome analysis identifies genes involved in ciliogenesis and the molecular cascade associated with intramuscular fat content in Large White heavy pigs.肌肉转录组分析鉴定了与大白猪肌肉内脂肪含量相关的纤毛发生和分子级联反应相关的基因。
PLoS One. 2020 May 19;15(5):e0233372. doi: 10.1371/journal.pone.0233372. eCollection 2020.
8
Exposure of Pancreatic β-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration.胰腺β细胞暴露于过量葡萄糖会导致mTORC1的双峰激活和mTOR依赖性代谢加速。
iScience. 2020 Feb 21;23(2):100858. doi: 10.1016/j.isci.2020.100858. Epub 2020 Jan 22.
9
Polyamine metabolism and cancer: treatments, challenges and opportunities.多胺代谢与癌症：治疗方法、挑战与机遇。
Nat Rev Cancer. 2018 Nov;18(11):681-695. doi: 10.1038/s41568-018-0050-3.
本文引用的文献
1
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.mTORC1依赖性的AMD1调节维持前列腺癌中的多胺代谢。
Nature. 2017 Jul 6;547(7661):109-113. doi: 10.1038/nature22964. Epub 2017 Jun 28.
2
Targeting polyamine metabolism for cancer therapy and prevention.靶向多胺代谢用于癌症治疗与预防。
Biochem J. 2016 Oct 1;473(19):2937-53. doi: 10.1042/BCJ20160383.
3
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age.通过一种随年龄增长而下降的机制，由多胺水平控制生物钟。
Cell Metab. 2015 Nov 3;22(5):874-85. doi: 10.1016/j.cmet.2015.09.011. Epub 2015 Oct 8.
4
Spermidine induces autophagy by inhibiting the acetyltransferase EP300.亚精胺通过抑制乙酰转移酶EP300诱导自噬。
Cell Death Differ. 2015 Mar;22(3):509-16. doi: 10.1038/cdd.2014.215. Epub 2014 Dec 19.
5
mTOR signaling in growth control and disease.mTOR 信号在生长控制和疾病中的作用。
Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.
6
Polyamines in aging and disease.衰老与疾病中的多胺
Aging (Albany NY). 2011 Aug;3(8):716-32. doi: 10.18632/aging.100361.
7
mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.mTOR 通过内部核糖体进入促进 IGF2 mRNA 翻译来磷酸化 IMP2。
Genes Dev. 2011 Jun 1;25(11):1159-72. doi: 10.1101/gad.2042311. Epub 2011 May 16.
8
Mammalian polyamine metabolism and function.哺乳动物的多胺代谢与功能。
IUBMB Life. 2009 Sep;61(9):880-94. doi: 10.1002/iub.230.
9
Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases.针对癌症及其他过度增殖性疾病中的多胺代谢与功能
Nat Rev Drug Discov. 2007 May;6(5):373-90. doi: 10.1038/nrd2243.
10
Polyamines and cancer: old molecules, new understanding.多胺与癌症：旧分子，新认识。
Nat Rev Cancer. 2004 Oct;4(10):781-92. doi: 10.1038/nrc1454.
Zotero 插件