具有超清洁石墨烯薄膜的霍尔效应生物传感器，可提高无标记 DNA 检测的灵敏度。
Hall effect biosensors with ultraclean graphene film for improved sensitivity of label-free DNA detection.
机构信息
Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, PR China; Physics Department, School of Education, Can Tho University, Can Tho City, Vietnam.
Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, PR China.
出版信息
Biosens Bioelectron. 2018 Jan 15;99:85-91. doi: 10.1016/j.bios.2017.07.045. Epub 2017 Jul 19.
The quality of graphene strongly affects the performance of graphene-based biosensors which are highly demanded for the sensitive and selective detection of biomolecules, such as DNA. This work reported a novel transfer process for preparing a residue-free graphene film using a thin gold supporting layer. A Hall effect device made of this gold-transferred graphene was demonstrated to significantly enhance the sensitivity (≈ 5 times) for hybridization detection, with a linear detection range of 1pM to 100nM for DNA target. Our findings provide an efficient method to boost the sensitivity of graphene-based biosensors for DNA recognition.
石墨烯的质量强烈影响基于石墨烯的生物传感器的性能，这些传感器对于生物分子（如 DNA）的灵敏和选择性检测有很高的需求。这项工作报道了一种使用薄金支撑层制备无残留石墨烯膜的新型转移工艺。所制备的金转移石墨烯的霍尔效应器件显著提高了杂交检测的灵敏度（≈5 倍），对 DNA 目标的线性检测范围为 1pM 至 100nM。我们的研究结果为提高基于石墨烯的生物传感器对 DNA 识别的灵敏度提供了一种有效的方法。
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