中药健脾理肝汤改善不可切除肝细胞癌射频消融术后生存率：一项回顾性研究
Chinese Herbal Medicine, Jian Pi Li Gan Decoction, Improved Survival of Nonresectable Hepatocellular Cancer After Radiofrequency Ablation: A Retrospective Study.
作者信息
Tang Chengwu, Feng Wenming, Qin Lianjin, Bao Ying
机构信息
1 First People's Hospital Affiliated to Huzhou Normal College, Huzhou, Zhejiang Province, People's Republic of China.
出版信息
Integr Cancer Ther. 2018 Jun;17(2):431-436. doi: 10.1177/1534735417722223. Epub 2017 Jul 26.
Abstract
OBJECTIVE
To observe the effect of Jian Pi Li Gan Decoction (JPLGD) on long-term survival of nonresectable hepatocellular cancer (HCC) after radiofrequency ablation (RFA).
METHODS
Between January 2010 and February 2013, 95 patients with nonresectable HCC treated by RFA in our hospital were enrolled, of whom 47 patients received JPLGD accompanying RFA (JPLGD group), and 48 patients received RFA alone (control group). Medical records of these patients were retrospectively analyzed. Long-term survival, complication, and treatment event were compared.
RESULTS
Baseline characteristics did not differ between the 2 groups. No significant adverse effects or toxicities related to herbal medicine were found. The JPLGD group had significantly less liver failure (3/47 vs 10/48, P = .0405) and a higher treatment success rate than the control group (44/47 vs 37/48, P = .0230). The 3-year overall survival probability was significantly higher in the JPLGD group ( P = .0175).
CONCLUSION
JPLGD has the potential to effectively and safely improve long-term survival of nonresectable HCC by increasing treatment success of RFA.
摘要
目的
观察健脾理肝汤（JPLGD）对不可切除肝细胞癌（HCC）射频消融（RFA）术后长期生存的影响。
方法
选取2010年1月至2013年2月在我院接受RFA治疗的95例不可切除HCC患者，其中47例患者在RFA的同时接受JPLGD治疗（JPLGD组），48例患者仅接受RFA治疗（对照组）。对这些患者的病历进行回顾性分析。比较两组患者的长期生存情况、并发症及治疗事件。
结果
两组患者的基线特征无差异。未发现与中药相关的明显不良反应或毒性。JPLGD组的肝衰竭发生率显著低于对照组（3/47 vs 10/48，P = 0.0405），治疗成功率高于对照组（44/47 vs 37/48，P = 0.0230）。JPLGD组的3年总生存概率显著更高（P = 0.0175）。
结论
JPLGD有可能通过提高RFA的治疗成功率，有效且安全地改善不可切除HCC的长期生存。
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