Erzurum Education and Research Hospital, Otorhinolaryngology Dept Erzurum, Turkey.
Am J Otolaryngol. 2013 Sep-Oct;34(5):416-9. doi: 10.1016/j.amjoto.2013.03.004. Epub 2013 Apr 30.
Allergic rhinitis is an IgE-mediated inflammatory disease which effects 10%-50% of the normal population. The mechanism of its formation and the circadian rhythm of cortisol and melatonin in allergic rhinitis have not been investigated.
Salivary levels of melatonin and cortisol were measured by radioimmunoassay in 35 newly diagnosed allergic rhinitis patients and in 23 control subjects matched for age and gender.
In the study group; amplitude, baseline and peak levels of salivary melatonin were significantly decreased compared with healty controls (p<0.001). No differences were found in the acrophase and the peak duration of salivary melatonin between the study and control groups (p>0.05). In the study subjects, the circadian rhythm of cortisol was flattened when compared with the control group. The amplitude and the 24h mean levels of salivary cortisol in the study group were significantly lower than in the control group and the acrophase was delayed in patients compared with control subjects (p<0.001).
The circadian rhythms of salivary melatonin and cortisol were found to be disrupted in patients with allergic rhinitis. These results may also be contributive data to explain the pathogenesis of allergic rhinitis and also they can be applicable as adjunctive therapeutic tools in the future and melatonin drugs might be an alternative in the therapy of resistant allergic rhinitis patients or allergic rhinitis patients who cannot use cortisol drugs.
过敏性鼻炎是一种 IgE 介导的炎症性疾病，影响 10%-50%的正常人群。其发病机制及皮质醇和褪黑素的昼夜节律尚未得到研究。
通过放射免疫分析法测量 35 例新诊断的过敏性鼻炎患者和 23 例年龄和性别匹配的健康对照者的唾液褪黑素和皮质醇水平。
在研究组中，唾液褪黑素的振幅、基线和峰值水平明显低于健康对照组（p<0.001）。研究组和对照组之间唾液褪黑素的峰相和峰期持续时间无差异（p>0.05）。与对照组相比，研究对象的皮质醇昼夜节律变平。研究组唾液皮质醇的振幅和 24 小时平均水平明显低于对照组，且患者的峰相延迟于对照组（p<0.001）。
过敏性鼻炎患者的唾液褪黑素和皮质醇昼夜节律被发现被打乱。这些结果也可能有助于解释过敏性鼻炎的发病机制，并且它们将来可以作为辅助治疗工具，褪黑素药物可能是治疗耐药性过敏性鼻炎患者或不能使用皮质醇药物的过敏性鼻炎患者的替代药物。
