Divyashree S, Gupta Nikhil
Former Assistant Professor of Medicine at the MS Ramaiah Medical College in Banagluru, Karnataka, India.
Fellow in Clinical Immunology & Rheumatology at the Christian Medical College in Vellore, India.
Perm J. 2017;21:16-139. doi: 10.7812/TPP/16-139.
Splenic abscesses are rare in immunocompetent adults. Despite advances in diagnosis and treatment, these abscesses are still potentially life threatening. Various factors have been reported to predispose otherwise immunocompetent adults to splenic abscesses. Splenectomy was once considered the "gold standard" treatment. However, the trend is shifting to a conservative approach.
We describe seven cases of splenic abscess in immunocompetent adults, the cause of which ranged from tuberculosis to salmonella and was as rare as Plasmodium vivax. All the patients presented with fever (median duration = one month; range = one week to six years) and abdominal pain, and most also had weight loss. All patients were in their third to fifth decades of life. The patients were successfully treated with appropriate antibiotic therapy, after which they were clinically normal.
A microbiological diagnosis of splenic abscess is of utmost importance. In this series, all patients underwent percutaneous aspiration. This was performed under radiologic guidance (either ultrasonography or computed tomography). Only one patient required diagnostic splenectomy. Irrespective of whatever surgical or nonsurgical drainage measures are employed, appropriate antibiotic therapy is the cornerstone of management. The dose and duration of antibiotic therapy depend on the causative organism and its sensitivity pattern.
脾脓肿在免疫功能正常的成年人中较为罕见。尽管在诊断和治疗方面取得了进展,但这些脓肿仍有潜在的生命危险。据报道,多种因素可使原本免疫功能正常的成年人易患脾脓肿。脾切除术曾被视为“金标准”治疗方法。然而,目前的趋势正转向保守治疗。
我们描述了7例免疫功能正常的成年脾脓肿患者,病因从结核到沙门氏菌不等,甚至还有间日疟原虫这种罕见病因。所有患者均有发热(中位持续时间 = 1个月;范围 = 1周 至6年)和腹痛,大多数患者还伴有体重减轻。所有患者年龄均在三十多岁至五十多岁。患者经适当的抗生素治疗后均获成功治愈,之后临床症状恢复正常。
脾脓肿的微生物学诊断至关重要。在本系列病例中,所有患者均接受了经皮穿刺抽吸。此操作在放射学引导下进行(超声或计算机断层扫描)。仅1例患者需要进行诊断性脾切除术。无论采用何种手术或非手术引流措施,适当的抗生素治疗都是治疗的基石。抗生素治疗的剂量和疗程取决于病原体及其药敏情况。