Zhou Yu-Juan, Yu Jing, Wu Yong-Zhen, Tian Liang, Han Zhao, Wang Jing, Chi Fang-Lu
Department of Otology and Skull Base Surgery, Eye Ear Nose & Throat Hospital, Fudan University, Shanghai, China.
Shanghai Auditory Medical Center, Shanghai, China.
PLoS One. 2017 Jul 26;12(7):e0181907. doi: 10.1371/journal.pone.0181907. eCollection 2017.
To investigate the relationship between mumps and the extent of hearing impairment and otolith organ damage.
A total of 27 patients with unilateral hearing impairment following mumps were enrolled. The degrees of hearing loss and otolith organ damage were confirmed by audiometric and vestibular evoked myogenic potential [VEMP] tests. All the results were compared and analyzed using Stata 13.0 software for Windows.
The VEMP thresholds of the affected ears were significantly higher than those of the unaffected ears in both tests (cervical VEMP [cVEMP] test and ocular VEMP [oVEMP] test; p = 0.000 and 0.001, respectively). The mean cVEMP and oVEMP threshold values of the affected ears with hearing impairment for ≤10 years were significantly lower than those of affected ears with hearing impairment for >10 years [p = 0.009 and 0.004, respectively].
Deafness resulting from mumps is usually profound and permanent, which indicates severe damage to the cochlea due to the disease. The functions of otolith organs in the vestibular system are also impaired. Over time, the function of the otolith organs or their neural pathway may suffer secondary damage.
探讨腮腺炎与听力损害程度及耳石器官损伤之间的关系。
共纳入27例腮腺炎后单侧听力损害患者。通过听力测定和前庭诱发肌源性电位（VEMP）测试确定听力损失程度和耳石器官损伤情况。所有结果均使用适用于Windows的Stata 13.0软件进行比较和分析。
在两项测试（颈性VEMP [cVEMP]测试和眼性VEMP [oVEMP]测试）中，患侧耳朵的VEMP阈值均显著高于未患侧耳朵（p值分别为0.000和0.001）。听力损害≤10年的患侧耳朵的平均cVEMP和oVEMP阈值显著低于听力损害>10年的患侧耳朵（p值分别为0.009和0.004）。
腮腺炎导致的耳聋通常严重且永久性，这表明该疾病对耳蜗造成了严重损害。前庭系统中耳石器官的功能也受到损害。随着时间的推移，耳石器官或其神经通路的功能可能会遭受继发性损害。
