Department of Public Health, Shiga University of Medical Science.
Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University.
J Atheroscler Thromb. 2018 Feb 1;25(2):186-198. doi: 10.5551/jat.40527. Epub 2017 Jul 26.
There are few data regarding associations between sleep duration and subclinical atherosclerosis in Japan. The aim of this study was to evaluate associations of self-reported sleep duration with calcification in the coronary arteries (CAC) and carotid intima media thickness (IMT) in Japanese men.
This was a cross-sectional survey of 1093 randomly selected men from Kusatsu City, Japan. Average sleep duration on weekdays was estimated through questionnaire; CAC by computed tomography; and carotid IMT by ultrasonography.
The prevalence of CAC was 50.0% for participants with sleep duration ＜5.5 h, 43.9% with 5.5-6.4 h, 50.0% with 6.5-7.4 h, 49.3% with 7.5-8.4 h, and 62.5% with ≥8.5 h. In univariate analysis, participants with sleep duration ≥8.5 h had significantly higher prevalence of CAC than those with 6.5-7.4 h (p=0.043). After adjustment for age and other risk factors, however, the association was not significant (p=0.776). The average IMT was 0.85 mm for participants with sleep duration ＜5.5 h, 0.83 mm with 5.5-6.4 h, 0.85 mm with 6.5-7.4 h, 0.88 mm with 7.5-8.4 h, and 0.90 mm with ≥8.5 h. None of the differences in IMT observed in crude or multivariable-adjusted analyses was significant (all p＞0.1).
Self-reported sleep duration was not associated with increased CAC or carotid IMT in a general population of Japanese men.
关于睡眠时间与亚临床动脉粥样硬化之间的关系，日本的数据较少。本研究的目的是评估日本男性自我报告的睡眠时间与冠状动脉钙化（CAC）和颈动脉内膜中层厚度（IMT）之间的关系。
这是一项对日本草津市随机选择的 1093 名男性进行的横断面调查。通过问卷调查估算工作日的平均睡眠时间；通过计算机断层扫描评估 CAC；通过超声检查评估颈动脉 IMT。
睡眠时长＜5.5 小时的参与者 CAC 患病率为 50.0%，5.5-6.4 小时的参与者为 43.9%，6.5-7.4 小时的参与者为 50.0%，7.5-8.4 小时的参与者为 49.3%，≥8.5 小时的参与者为 62.5%。单因素分析显示，睡眠时长≥8.5 小时的参与者 CAC 患病率显著高于 6.5-7.4 小时的参与者（p=0.043）。然而，在调整年龄和其他危险因素后，这种关联并不显著（p=0.776）。睡眠时长＜5.5 小时的参与者平均 IMT 为 0.85 毫米，5.5-6.4 小时的参与者为 0.83 毫米，6.5-7.4 小时的参与者为 0.85 毫米，7.5-8.4 小时的参与者为 0.88 毫米，≥8.5 小时的参与者为 0.90 毫米。在未经调整和多变量调整的分析中，IMT 的差异均无统计学意义（所有 p＞0.1）。
在日本男性的一般人群中，自我报告的睡眠时间与 CAC 或颈动脉 IMT 的增加无关。
