School of Medicine, Universidad Espíritu Santo - Ecuador, Guayaquil, Ecuador.
Department of Epidemiology, Gilead Sciences, Inc., Foster City, California.
J Clin Sleep Med. 2019 Aug 15;15(8):1101-1106. doi: 10.5664/jcsm.7798.
Evidence of an association between atherosclerosis and sleep quality is limited and has not been studied in remote rural settings, where living conditions are different than in urban centers. We aimed to assess the relationship between the aortic pulse wave velocity (PWV) and sleep quality in older adults living in rural Ecuador.
Atahualpa residents aged 60 years or older identified during door-to-door surveys, who consented to participate, underwent face-to-face interviews with the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality. Aortic PWV determinations were performed for arterial stiffness estimation (as a surrogate of atherosclerosis).
A total of 303 individuals were included (mean age: 70.3 ± 7.8 years; 59% women). Univariate logistic regression showed a significant association between the aortic PWV and poor sleep quality (odds ratio [OR] 1.22; 95% confidence interval [CI] 1.07-1.39; P = .003). A multivariate logistic regression model, adjusted for demographics, cardiovascular risk factors, oily fish intake and psychological distress showed a significant association between increased PWV and poor sleep quality (OR 1.59; 95% CI 1.12-2.25; P = .009). Similar significance was noted when the model was adjusted for neuroimaging signatures of cerebral small-vessel disease and stroke (OR 1.47; 95% CI 1.07-2.03; P = .019).
This study shows a significant independent association between the aortic PWV and poor sleep quality in older adults living in rural Ecuador. Results provide more insights into the relevance of the impact of sleep disorders on cardiovascular diseases.
The Atahualpa Project has been registered at ClinicalTrials.gov. The identifier number is NCT01627600, and the date was: 10/02/2012.
Del Brutto OH, Mera RM, Peñaherrera E, Costa AF, Peñaherrera R, Castillo PR. On the association between sleep quality and arterial stiffness: a population study in community-dwelling older adults living in rural ecuador (the atahualpa project). J Clin Sleep Med. 2019;15(8):1101-1106.
动脉粥样硬化与睡眠质量之间的关联证据有限，并且尚未在生活条件与城市中心不同的偏远农村地区进行研究。我们旨在评估厄瓜多尔农村老年人的主动脉脉搏波速度（PWV）与睡眠质量之间的关系。
在挨家挨户调查中确定的年龄在 60 岁或以上的 Atahualpa 居民，如果同意参加，将接受面对面的匹兹堡睡眠质量指数（PSQI）访谈，以评估睡眠质量。进行主动脉 PWV 测定以评估动脉僵硬度（作为动脉粥样硬化的替代指标）。
共纳入 303 人（平均年龄：70.3±7.8 岁；59%为女性）。单变量逻辑回归显示，主动脉 PWV 与睡眠质量差有显著关联（比值比 [OR] 1.22；95%置信区间 [CI] 1.07-1.39；P=0.003）。在调整人口统计学、心血管危险因素、油性鱼类摄入量和心理困扰的多变量逻辑回归模型中，PWV 增加与睡眠质量差之间存在显著关联（OR 1.59；95%CI 1.12-2.25；P=0.009）。当模型调整为脑小血管疾病和中风的神经影像学特征时，也观察到类似的显著性（OR 1.47；95%CI 1.07-2.03；P=0.019）。
这项研究表明，厄瓜多尔农村老年人的主动脉 PWV 与睡眠质量差之间存在显著的独立关联。结果提供了更多关于睡眠障碍对心血管疾病影响的见解。
Atahualpa 项目已在 ClinicalTrials.gov 注册。标识符编号为 NCT01627600，日期为：2012 年 10 月 2 日。
Del Brutto OH, Mera RM, Peñaherrera E, Costa AF, Peñaherrera R, Castillo PR. On the association between sleep quality and arterial stiffness: a population study in community-dwelling older adults living in rural ecuador (the atahualpa project). J Clin Sleep Med. 2019;15(8):1101-1106.
