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精神分裂症特质轨迹及其情绪和社会功能:一项为期 18 个月的随访研究。

Trajectories of schizotypy and their emotional and social functioning: An 18-month follow-up study.

机构信息

Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.

North China Electric Power University, Beijing, China.

出版信息

Schizophr Res. 2018 Mar;193:384-390. doi: 10.1016/j.schres.2017.07.038. Epub 2017 Jul 24.

DOI:10.1016/j.schres.2017.07.038
PMID:28751128
Abstract

Schizotypy is a set of personality traits that convey liability to develop schizophrenia. Studying schizotypy in healthy individuals may facilitate the understanding of the psychopathological processes underlying schizophrenia. The present study aimed to examine the developmental trajectories of schizotypy over time using a longitudinal study design. The Chapman Scales for Psychosis Proneness were administered to 1541 college students at baseline, and subsequently at six-monthly intervals up to 18months. Latent class growth analysis was conducted to track the different trajectories. In addition, self-reported scales were used to measure idea of reference, emotional experiences and expression, stress and coping, as well as social functioning. We identified four latent classes with distinct trajectories: "nonschizotypy" group (LC1), "stable high schizotypy" group (LC3), "high reactive schizotypy" group (LC2) and "low reactive schizotypy" group (LC4). These findings suggest that there may be distinct developmental trajectories for schizotypy. Two groups may be of particular interest: the "stable high schizotypy" group that displayed the worst clinical and functioning outcomes on almost all measures and the "high reactive schizotypy" group characterized by a relatively rapid decline in functioning.

摘要

分裂型特质是一组人格特质,表明有发展为精神分裂症的倾向。研究健康个体中的分裂型特质可以促进对精神分裂症潜在病理过程的理解。本研究旨在使用纵向研究设计,考察分裂型特质随时间的发展轨迹。在基线时,向 1541 名大学生发放了 Chapman 精神易感性量表,并随后每六个月测量一次,直至 18 个月。采用潜在类别增长分析来追踪不同的轨迹。此外,还使用自我报告量表测量观念关联、情绪体验和表达、压力和应对以及社会功能。我们确定了具有不同轨迹的四个潜在类别:“非分裂型特质”组(LC1)、“稳定高分裂型特质”组(LC3)、“高反应性分裂型特质”组(LC2)和“低反应性分裂型特质”组(LC4)。这些发现表明,分裂型特质可能存在不同的发展轨迹。有两个组可能特别有趣:“稳定高分裂型特质”组,在几乎所有测量指标上都表现出最差的临床和功能结果;“高反应性分裂型特质”组的功能下降较快。

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