Gokyer Ali, Kostek Osman, Hacioglu Muhammet Bekir, Erdogan Bulent, Kodaz Hilmi, Turkmen Esma, Hacibekiroglu Ilhan, Uzunoglu Sernaz, Cicin Irfan
Department of Internal Medicine, Trakya University Faculty of Medicine, Edirne, Turkey.
Division of Medical Oncology, Department of Internal Medicine, Trakya University, Balkan Oncology Hospital, Edirne, Turkey.
North Clin Istanb. 2017 May 10;4(1):43-51. doi: 10.14744/nci.2017.67044. eCollection 2017.
Multiple primary tumors are the ones that develop in the same patient at the same or different times. They are usually examined under two groups. If the second tumor is diagnosed 6 months after the first tumor is diagnosed, it is named as metachronous tumor. If it is diagnosed in 6 months after the first diagnosis, it is called as synchronous tumor. The malignancy of tumors should be proved histologically. At least 2 cm of solid tissue should be present between two tumors. If they are at localized at the same place, a gap of at least 5 years should be present between them. Metastatic disease should be eliminated. This study aimedto review the clinical, demographic, and pathological features of multiple primary tumors, detect the prevalence, compare the results with literature findings, and evaluate and improve the approach to multiple primary tumors.
A total of 170 patients diagnosed with multiple primary tumors were included in this study. Patient data were obtained from pathology and medical reports of the patients.
Most of the multiple primary tumors were metachronous. The number of male patients was more than that of female patients. The median time between double tumors was 3 monthsforsynchronous tumorsand 26 months for metachronous tumors. Synchronous tumors with the highest prevalence of comorbidity were lung-larynx and lung-colon, whereas metachronous tumors with the highest prevalence of comorbidity were lung-bladder, lung-larynx, breast-endometrium, and breast-colon. The history of smoking and alcohol was found to be higher in male patients andsynchronous tumors.
The detection of the first tumor in the metastatic stage and an accompanying synchronous secondary tumor was found to be a poor prognostic factor. The treatment of the first tumor, smoking, squamous cell histology, and male gender were among the other factors negatively affecting survival, although they were not statistically significant.
多发性原发性肿瘤是指在同一患者体内于相同或不同时间发生的肿瘤。它们通常分为两组进行检查。如果第二个肿瘤在第一个肿瘤确诊后6个月被诊断出来，则称为异时性肿瘤。如果在首次诊断后的6个月内被诊断出来，则称为同时性肿瘤。肿瘤的恶性程度应由组织学证实。两个肿瘤之间至少应有2厘米的实体组织。如果它们位于同一部位，则它们之间应有至少5年的间隔。应排除转移性疾病。本研究旨在回顾多发性原发性肿瘤的临床、人口统计学和病理特征，检测其患病率，将结果与文献研究结果进行比较，并评估和改进对多发性原发性肿瘤的处理方法。
本研究共纳入170例被诊断为多发性原发性肿瘤的患者。患者数据来自患者的病理报告和医疗报告。
大多数多发性原发性肿瘤为异时性肿瘤。男性患者数量多于女性患者。同时性肿瘤的双肿瘤之间的中位时间为3个月，异时性肿瘤为26个月。合并症患病率最高的同时性肿瘤是肺-喉和肺-结肠，而异时性肿瘤是肺-膀胱、肺-喉、乳腺-子宫内膜和乳腺-结肠。发现男性患者和同时性肿瘤的吸烟和饮酒史较高。
在转移阶段发现第一个肿瘤并伴有同时性继发性肿瘤被发现是一个不良预后因素。第一个肿瘤的治疗、吸烟、鳞状细胞组织学和男性性别是其他对生存有负面影响的因素，尽管它们在统计学上不显著。
