Toy Seyma, Ozbag Davut, Altay Zuhal
Department of Physical Therapy and Rehabilitation, Inonu University Faculty of Medicine, Malatya, Turkey.
Department of Anatomy, Inonu University Faculty of Medicine, Malatya, Turkey.
North Clin Istanb. 2017 May 10;4(1):52-59. doi: 10.14744/nci.2017.27122. eCollection 2017.
This study was an investigation of effects of pre-obesity on clinical characteristics and quality of life in patients with ankylosing spondylitis (AS).
Total of 28 AS patients and 30 age- and sex-matched healthy controls were included in the study. Patients and controls with any systemic inflammatory disease and/or cognitive and mental problems were excluded. Disease activity and functional capacity were measured using the Bath Ankylosing Spondylitis Disease Activity Index and Bath Ankylosing Spondylitis Functional Index. For quality of life assessment, 36-Item Short Form Health Survey was used in both groups, and AS group also responded to Ankylosing Spondylitis Quality of Life questionnaire.
There was no significant difference in sociodemographic characteristics between AS patients and healthy controls (p>0.05). Mean quality of life scores were significantly lower in the pre-obese AS patients compared with controls (p<0.05). Functional capacity was positively and significantly associated with body mass index (BMI) (p=0.024) and disease activity was significantly associated with female gender (p=0.011).
Increased BMI in patients with AS is factor that affects quality of life, disease activity, and functional capacity. Multidisciplinary rehabilitation programs will support improved quality of life for pre-obese patients with AS.
本研究旨在调查肥胖前期对强直性脊柱炎（AS）患者临床特征及生活质量的影响。
本研究纳入了28例AS患者和30例年龄及性别匹配的健康对照者。排除患有任何全身性炎症性疾病和/或认知及精神问题的患者及对照者。采用巴斯强直性脊柱炎疾病活动指数和巴斯强直性脊柱炎功能指数来测量疾病活动度和功能能力。两组均使用36项简明健康调查问卷进行生活质量评估，AS组还需回答强直性脊柱炎生活质量问卷。
AS患者与健康对照者在社会人口学特征方面无显著差异（p>0.05）。肥胖前期AS患者的平均生活质量得分显著低于对照组（p<0.05）。功能能力与体重指数（BMI）呈显著正相关（p=0.024），疾病活动度与女性性别显著相关（p=0.011）。
AS患者BMI升高是影响生活质量、疾病活动度和功能能力的一个因素。多学科康复计划将有助于改善肥胖前期AS患者的生活质量。
