Department of Rheumatology, El Ayachi Hospital, University Hospital of Rabat, Sale, 11000, Morocco.
Clin Rheumatol. 2011 May;30(5):673-7. doi: 10.1007/s10067-010-1613-1. Epub 2010 Oct 31.
The main objective of this study was to assess the aspects of health-related quality of life (QOL) in patients with ankylosing spondylitis (AS) and to explore the disease-related parameters influencing it. One hundred patients with AS according to New York Classification criteria were recruited in this cross-sectional study. The Medical Outcomes Study Short Form 36 Health Survey (SF-36) was used to assess health-related QOL. Assessment criteria included the evaluation of disease activity (Bath Ankylosing Spondylitis Disease Activity index [BASDAI]), global well-being (Bath Ankylosing Spondylitis Global Index [BASGI]), enthesitis (Mander enthesis index [MEI]), functional status (Bath Ankylosing Spondylitis Functional Index [BASFI]); metrology (Bath Ankylosing Spondylitis Metrology Index [BASMI]) and radiographic damage (Bath Ankylosing Spondylitis Radiologic Index [BASRI]). In this study, males comprised 67% of the subjects; mean age was 38 ± 13 years and mean disease duration was 9.5 ± 6.8 years. Among these patients, 52% had hip involvement. Our patients had a moderately active disease and severe functional disability. All domains of SF-36 were deteriorated with low scores. The SF-36 subgroups most affected were role limitation (18.8 ± 28.1), role emotional (19.4 ± 35), general health (44.9 ± 20.3) and vitality (38.0 ± 18.2). Lower scores of SF-36 had good statistically significant correlations with altered functional status (BASFI), worse general well-being (BASGI), altered metrology (BASMI); and moderate correlations with high disease activity (BASDAI), important radiological damage (BASRI); restricted chest expansion and prolonged morning stiffness (p < 0.001). This study states that health-related QOL in Moroccan patients with AS is damaged in a significant way. Mental as well as physical aspects were affected. Functional disability, patient's well-being, metrology and disease activity are the main factors associated with deteriorating domains of QOL in AS. Recognizing complicated relationships between clinical measures and QOL in patients with AS can help us to develop further management strategies to improve their QOL.
本研究的主要目的是评估强直性脊柱炎（AS）患者的健康相关生活质量（QOL）方面，并探讨影响其生活质量的疾病相关参数。在这项横断面研究中，我们招募了 100 名符合纽约分类标准的 AS 患者。采用健康研究简表 36 项健康调查（SF-36）评估健康相关 QOL。评估标准包括疾病活动度评估（Bath 强直性脊柱炎疾病活动指数 [BASDAI]）、整体幸福感（Bath 强直性脊柱炎全球指数 [BASGI]）、肌腱炎（Mander 肌腱炎指数 [MEI]）、功能状态（Bath 强直性脊柱炎功能指数 [BASFI]）、计量学（Bath 强直性脊柱炎计量学指数 [BASMI]）和放射学损伤（Bath 强直性脊柱炎放射学指数 [BASRI]）。在本研究中，男性占 67%；平均年龄为 38 ± 13 岁，平均病程为 9.5 ± 6.8 年。这些患者中有 52%有髋关节受累。我们的患者疾病活动度中度活跃，功能障碍严重。SF-36 的所有领域评分均较低，功能均受损。受影响最严重的 SF-36 亚组是角色限制（18.8 ± 28.1）、角色情绪（19.4 ± 35）、总体健康（44.9 ± 20.3）和活力（38.0 ± 18.2）。SF-36 评分较低与功能状态（BASFI）改变、整体健康状况恶化（BASGI）、计量学改变（BASMI）有良好的统计学显著相关性；与疾病活动度高（BASDAI）、放射学损伤显著（BASRI）、胸廓扩张受限和晨僵时间延长有中度相关性（p < 0.001）。本研究表明，摩洛哥 AS 患者的健康相关 QOL 受到严重损害。心理和生理方面都受到影响。功能障碍、患者的幸福感、计量学和疾病活动度是与 AS 患者 QOL 恶化相关的主要因素。认识到 AS 患者临床指标与 QOL 之间复杂的关系，有助于我们制定进一步的管理策略，以改善他们的 QOL。
