Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
Adv Mater. 2017 Oct;29(37). doi: 10.1002/adma.201606596. Epub 2017 Jul 28.
The delivery of drugs to a target site frequently involves crossing biological barriers. The degree and nature of the impediment to flux, as well as the potential approaches to overcoming it, depend on the tissue, the drug, and numerous other factors. Here an overview of approaches that have been taken to crossing biological barriers is presented, with special attention to transdermal drug delivery. Technology and knowledge pertaining to addressing these issues in a variety of organs could have a significant clinical impact.
药物递送到靶位通常涉及穿过生物屏障。通量的阻碍程度和性质，以及克服它的潜在方法，取决于组织、药物和许多其他因素。本文概述了已经采取的穿过生物屏障的方法，特别关注经皮药物传递。解决这些问题的技术和知识可能会对各种器官产生重大的临床影响。
