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本文引用的文献

1
XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning.作为诊断为铅中毒儿童铅暴露和毒性生物标志物的X射线荧光测定骨铅（Pb）
Biomarkers. 2016;21(4):347-52. doi: 10.3109/1354750X.2016.1139183. Epub 2016 Feb 9.
2
Portable XRF Technology to Quantify Pb in Bone In Vivo.便携式X射线荧光光谱技术用于体内定量检测骨中的铅含量。
J Biomark. 2014;2014:398032. doi: 10.1155/2014/398032. Epub 2014 Nov 27.
3
Measurements of fluorine in contemporary urban Canadians: a comparison of the levels found in human bone using in vivo and ex vivo neutron activation analysis.当代加拿大城市居民氟含量的测量：使用体内和体外中子活化分析对人体骨骼中氟含量水平的比较。
Physiol Meas. 2015 Mar;36(3):465-87. doi: 10.1088/0967-3334/36/3/465. Epub 2015 Feb 11.
4
Design of a phantom equivalent to measure bone-fluorine in a human's hand via delayed neutron activation analysis.设计一个仿体，通过延迟中子活化分析来测量人手上的骨氟。
Physiol Meas. 2013 May;34(5):503-12. doi: 10.1088/0967-3334/34/5/503. Epub 2013 Apr 15.
5
In vivo quantification of lead in bone with a portable x-ray fluorescence system--methodology and feasibility.利用便携式 X 射线荧光系统对骨骼中的铅进行体内定量——方法学和可行性。
Phys Med Biol. 2011 Feb 7;56(3):N39-51. doi: 10.1088/0031-9155/56/3/N01. Epub 2011 Jan 17.
6
Strontium is incorporated into mineral crystals only in newly formed bone during strontium ranelate treatment.锶仅在锶雷奈酸酯治疗期间新形成的骨的矿物质晶体中被结合。
J Bone Miner Res. 2010 May;25(5):968-75. doi: 10.1359/jbmr.091038.
7
In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization.在接受雷奈酸锶治疗的骨质疏松女性中，锶位于治疗期间形成的具有维持程度矿化的骨中。
Osteoporos Int. 2010 Apr;21(4):667-77. doi: 10.1007/s00198-009-1005-z. Epub 2009 Jul 14.
8
Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone.在猴子中长期给予雷奈酸锶可保留骨矿物质晶体的特性和骨矿化程度。
J Bone Miner Res. 2005 Sep;20(9):1569-78. doi: 10.1359/JBMR.050405. Epub 2005 Apr 27.
9
Impact of occupational exposure on lead levels in women.职业暴露对女性铅含量的影响。
Environ Health Perspect. 2005 Apr;113(4):478-84. doi: 10.1289/ehp.7386.
10
Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study.雷奈酸锶降低绝经后骨质疏松症女性非椎体骨折风险：外周骨质疏松症治疗（TROPOS）研究。
J Clin Endocrinol Metab. 2005 May;90(5):2816-22. doi: 10.1210/jc.2004-1774. Epub 2005 Feb 22.

利用便携式 X 射线荧光（XRF）技术对人体骨骼中的锶含量进行活体测量。

Measurements of Strontium Levels in Human Bone In Vivo Using Portable X-ray Fluorescence (XRF).

机构信息

1 School of Health Sciences, Purdue University, West Lafayette, IN USA.

2 Harvard T.H. Chan School of Public Health, Boston, MA, USA.

出版信息

Appl Spectrosc. 2017 Aug;71(8):1962-1968. doi: 10.1177/0003702817694383. Epub 2017 Mar 2.

DOI:10.1177/0003702817694383
PMID:28756702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5617116/
Abstract

Measurement of bone strontium (Sr) is vital to determining the effectiveness of Sr supplementation, which is commonly used for the treatment of osteoporosis. Previous technology uses radioisotope sources and bulky equipment to measure bone Sr. This study demonstrates the effectiveness of portable X-ray fluorescence (XRF) for bone Sr measurement and validates it using data from a population of 238 children. We identified correlations between bone Sr and age in our participants.

摘要

测量骨骼中的锶（Sr）对于评估锶补充剂的有效性至关重要，锶补充剂常用于治疗骨质疏松症。以往的技术使用放射性同位素源和大型设备来测量骨骼中的 Sr。本研究展示了便携式 X 射线荧光（XRF）技术在骨骼 Sr 测量中的有效性，并使用 238 名儿童的数据进行了验证。我们在研究对象中发现了骨骼 Sr 与年龄之间的相关性。

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